LC/MS characterization of rotenone induced cardiolipin oxidation in human lymphocytes: Implications for mitochondrial dysfunction associated with Parkinson's disease
Article first published online: 3 MAY 2013
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Special Issue: Lipidomics: Approaches and Applications in Nutrition Research
Volume 57, Issue 8, pages 1410–1422, August 2013
How to Cite
Tyurina, Y. Y., Winnica, D. E., Kapralova, V. I., Kapralov, A. A., Tyurin, V. A. and Kagan, V. E. (2013), LC/MS characterization of rotenone induced cardiolipin oxidation in human lymphocytes: Implications for mitochondrial dysfunction associated with Parkinson's disease. Mol. Nutr. Food Res., 57: 1410–1422. doi: 10.1002/mnfr.201200801
- Issue published online: 2 AUG 2013
- Article first published online: 3 MAY 2013
- Manuscript Accepted: 27 FEB 2013
- Manuscript Revised: 26 FEB 2013
- Manuscript Received: 4 DEC 2012
- NIH. Grant Numbers: ES020693, HL70755, U19AIO68021
- NIOSH. Grant Number: OH008282
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Figure S1 Identification of CL molecular species by LC/MS. MS/MS spectra of CL molecular ions with m/z 1447.5 (upper panel) and 1475.5 (lower panel).
Figure S2 Identification of oxygenated TLCL molecular species by LC-MS. MS/MS spectrum and base peak profile (insert) of CL molecular ions with m/z 1463.9 corresponding to mono-oxygenated TLCL.
Figure S3 Identification of oxygenated fatty acids after hydrolysis of CL with PLA1. MS/MS spectrum of molecular ions with m/z 295 corresponding to mono-oxygenated C18:2 (9-10-epoxy, 11-octadecenoic acid).
Figure S4 Identification of oxygenated fatty acids after hydrolysis of CL with PLA2. MS/MS spectrum of molecular ions with m/z 311 corresponding to di-oxygenated C18:2 (8,13-dihydroxy-9,11-octadecadienoic acid).
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