Effects of chocolate supplementation on metabolic and cardiovascular parameters in ApoE3L mice fed a high-cholesterol atherogenic diet
Article first published online: 15 AUG 2013
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 57, Issue 11, pages 2039–2048, November 2013
How to Cite
Yakala, G. K., Wielinga, P. Y., Suarez, M., Bunschoten, A., van Golde, J. M., Arola, L., Keijer, J., Kleemann, R., Kooistra, T. and Heeringa, P. (2013), Effects of chocolate supplementation on metabolic and cardiovascular parameters in ApoE3L mice fed a high-cholesterol atherogenic diet. Mol. Nutr. Food Res., 57: 2039–2048. doi: 10.1002/mnfr.201200858
- Issue published online: 28 OCT 2013
- Article first published online: 15 AUG 2013
- Manuscript Accepted: 17 MAY 2013
- Manuscript Revised: 5 APR 2013
- Manuscript Received: 27 DEC 2012
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|mnfr2034-sup-0001-FigureS1.pptx||11020K||Figure 1. Effect of chocolates on kidney weight, morphology and function at week 20. (a) Kidney weight, (b) Morphology of the kidney (PAS staining) (n = 8), (c) Kidney function (albuminuria), and (d) Immunohistochemistry of macrophage infiltrates (200x) (n = 5). Groups are abbreviated as: Mice fed control diet without cholesterol (CO, n = 19); mice fed control diet (i.e. with 1% cholesterol) (CC, n = 19); mice fed control diet supplemented with choc A (CCA, n = 19) and mice fed control diet supplemented with choc B (CCB, n = 19).|
|mnfr2034-sup-0002-TableS1.docx||41K||Table 1. Composition of the chocolate diets used in this study.|
Table 2A. Optimized SRM conditions for the analyses of the studied phenolic compounds by HPLC–MS/MS.
Table 2B. Optimized SRM conditions for the analyses of the selected metabolites by HPLC–MS/MS.
|mnfr2034-sup-0004-TableS3.docx||35K||Table 3. Quantification of chocolate plasma metabolites (values expressed as nM in the plasma sample)|
|mnfr2034-sup-0005-TableS4.docx||309K||Table 4. Dietary composition of basic atherogenic diet without cholesterol|
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