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Table S1. Composition of the experimental diets

Table S2. Primer sequences for qRT-PCR

Figure S1. Serum (A) glucose and (B) lactate dehydrogenase (LDH) levels of WT and ApoE―/― mice fed a high fat diet (HFD) and HFD supplemented with genistein (GEN) (0.5 g/kg diet) for 24 weeks. Data are presented as means ± SEM (n = 5–7 per group). *Significantly different from genotype-matched mice (P < 0.05).

Figure S2. Relation between (A) serum total cholesterol levels and relative p-IκBα protein levels, (B) serum total cholesterol levels and hepatic monocyte chemoattractant protein 1 (MCP-1) mRNA levels, (C) serum total cholesterol levels and hepatic tumor necrosis factor alpha (TNFα) mRNA levels, and (D) serum total cholesterol levels and hepatic cyclooxygenase 2 (COX-2) mRNA levels of WT and ApoE―/― mice fed a high fat diet (HFD) and HFD supplemented with genistein (GEN) (0.5 g/kg diet) for 24 weeks. Pearson correlation coefficient, r, and P-value are indicated for each region (A: n = 3 per group, B-D: n = 5, 6 per group).

Figure S3. Relation between (A) hepatic triglyceride levels and hepatic CD36 mRNA levels, and (B) hepatic triglyceride levels and monoacylglycerol O-acyltransferase 1 (MGAT1) mRNA levels of WT and ApoE―/― mice fed a high fat diet (HFD) and HFD supplemented with genistein (GEN) (0.5 g/kg diet) for 24 weeks. Pearson correlation coefficient, r, and P-value are indicated for each region (n = 5, 6 per group).

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