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Supporting Information Fig. 2

Table 1. Physiological and physic-chemical parameters used in the PBKK model for estragole in rat.

Table 2. Physiological and physic-chemical parameters used in the PBKK model for estragole in human.

Table 3. Physiological and physic-chemical parameters used in the PBKK model for nevadensin in rat.

Table 4. Physiological and physic-chemical parameters used in the PBKK model for nevadensin in human.

Table 5. Kinetic constants for estragole metabolism by human and male rat tissue fractions.

Table 6. Kinetic constants for nevadensin metabolism by human and male rat tissue fractions.

Table 7. Overview of the data from Miller et al. (1983) [11]on the incidence of hepatomas in female mice exposed for 12 months via the diet to estragole and of the estimated refined incidences obtained based on the PBBK model based predicted reduction in DNA adduct formation in the presence of nevadensin at a molar ratio of estragole to nevadensin of 1:0.25 respectively.

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