Wolfberries potentiate mitophagy and enhance mitochondrial biogenesis leading to prevention of hepatic steatosis in obese mice: The role of AMP-activated protein kinase α2 subunit
Version of Record online: 22 JAN 2014
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 58, Issue 5, pages 1005–1015, May 2014
How to Cite
Lin, D., He, H., Ji, H., Willis, J., Willard, L., Jiang, Y., Medeiros, D. M., Wark, L., Han, J., Liu, Y. and Lu, B. (2014), Wolfberries potentiate mitophagy and enhance mitochondrial biogenesis leading to prevention of hepatic steatosis in obese mice: The role of AMP-activated protein kinase α2 subunit. Mol. Nutr. Food Res., 58: 1005–1015. doi: 10.1002/mnfr.201300186
- Issue online: 22 APR 2014
- Version of Record online: 22 JAN 2014
- Manuscript Accepted: 14 NOV 2013
- Manuscript Revised: 10 NOV 2013
- Manuscript Received: 12 MAR 2013
- NIH NCRR. Grant Number: P20-RR-017686
- National Basic Research Program of China. Grant Number: 2013CB531702
- National Natural Science Foundation of China. Grant Numbers: 31070710, 31171345
- Zhejiang Qianjiang Talent Project B. Grant Number: 2010R10045
- Scientific Research Foundation for the Returned Overseas Chinese Scholar, State Education Ministry (BL)
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Table S1. Composition of the control diet (CD, 10 % [kcal] fat), high fat diet (HD, 45% [kcal] fat), and wolfberry diet (WD, the HD with 5% [kcal] wolfberries), formulated by Research Diets, Inc.
Table S2. Food consumption (gram/mouse/day) of the wild type C57BL/6J (B6) and AMPKα2 knockout (KO) mice CD, the control diet (10 % [kcal] fat); HD, high fat diet (45% [kcal] fat); WD, wolfberry diet (the HD with 5% [kcal] wolfberries)
Figure S1. Dietary wolfberry does not lower body weight gain and amounts of epididymal adipose tissues in C57BL/6J (B6) and AMPKα2 knockout (KO) mice fed the high fat diet (HD).
Figure S2. Dietary wolfberry does not alter hepatic AMPKα protein expression and AMPKα1 activity in C57BL/6J (B6) and AMPKα2 knockout (KO) mice.
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