Polymorphisms in the SCD1 gene are associated with indices of stearoyl CoA desaturase activity and obesity: A prospective study
Article first published online: 12 AUG 2013
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 57, Issue 12, pages 2177–2184, December 2013
How to Cite
Martín-Núñez, G. M., Cabrera-Mulero, R., Rojo-Martínez, G., Gómez-Zumaquero, J. M., Chaves, F. J., de Marco, G., Soriguer, F., Castaño, L. and Morcillo, S. (2013), Polymorphisms in the SCD1 gene are associated with indices of stearoyl CoA desaturase activity and obesity: A prospective study. Mol. Nutr. Food Res., 57: 2177–2184. doi: 10.1002/mnfr.201300208
- Issue published online: 4 DEC 2013
- Article first published online: 12 AUG 2013
- Manuscript Accepted: 12 JUN 2013
- Manuscript Revised: 11 JUN 2013
- Manuscript Received: 20 MAR 2013
- Fondo de Investigación Sanitaria. Grant Number: PS09/02117
- CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM). Grant Number: CB07/08/0019
- Olive oil;
- Prospective study;
- Stearoyl CoA desaturase
The serum fatty acid (FA) composition is influenced by dietary fat and the endogenous production of FAs. Stearoyl CoA desaturase 1 (SCD1) is the rate-limiting enzyme catalyzing the synthesis of MUFAs from saturated FAs. Variations in SCD1 activity have been associated with obesity, diabetes, or inflammation. We evaluated the associations between genetic variation of the SCD1 gene, SCD1 activity, intake of oil, and obesity in a population-based prospective study in southern Spain.
Methods and results
We collected phenotypic, metabolic, nutritional, and genetic information. The type of dietary fat was assessed from samples of cooking oil taken from the participants’ kitchens and analyzed by GC. A total of nine single nucleotide polymorphisms (SNPs) of the SCD1 gene were analyzed by SNPlex technology. We found a significant association between SCD1 genetic variation and enzyme activity in four of nine polymorphisms studied. An interaction between rs10883463 and olive oil intake on the [18:1/18:0] desaturase index was found (p = 0.009). We also showed that genetic variations in the SCD1 gene were associated with obesity.
Our results show a relationship between genetic variation of the SCD1 gene, enzyme activity, and the risk of obesity, an association that is not independent of the type of oil consumed.