Protective effect of a pomace olive oil concentrated in triterpenic acids in alterations related to hypertension in rats: Mechanisms involved
Article first published online: 4 SEP 2013
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 58, Issue 2, pages 376–383, February 2014
How to Cite
Valero-Muñoz, M., Martín-Fernández, B., Ballesteros, S., de la Fuente, E., Quintela, J. C., Lahera, V. and de las Heras, N. (2014), Protective effect of a pomace olive oil concentrated in triterpenic acids in alterations related to hypertension in rats: Mechanisms involved. Mol. Nutr. Food Res., 58: 376–383. doi: 10.1002/mnfr.201300256
- Issue published online: 3 FEB 2014
- Article first published online: 4 SEP 2013
- Manuscript Revised: 16 JUL 2013
- Manuscript Accepted: 16 JUL 2013
- Manuscript Received: 11 APR 2013
- Comisión Interministerial de Ciencia y Tecnología de España. Grant Number: SAF2011-30396
- Ministerio de Ciencia e Innovación. Grant Number: IPT-2011-1262-06000
- Endothelial dysfunction;
- Pomace olive oil;
- Triterpenic acids
Despite the amount of information and research on the effects of virgin olive oil and its components in cardiovascular disease, little attention has been paid to the effects of pomace olive oil, an olive oil subproduct traditionally used in Spain. The aim of the present study was to evaluate the potential effects of a pomace olive oil concentrated in triterpenic acids (POCTA) on blood pressure, cardiac hemodynamics, and functional and molecular vascular alterations associated with hypertension in spontaneously hypertensive rats (SHR).
Methods and results
The study showed that POCTA attenuated the increase of blood pressure in SHR. This effect was associated with an improvement in endothelium-dependent relaxation, enhancement of vascular expression of endothelial nitric oxide synthase, and reduction of tumor necrosis factor alpha, transforming growth factor beta, and collagen I. Furthermore, POCTA improved cardiac hemodynamics (left ventricular systolic pressure and left ventricular end-diastolic pressure) and decreased relative kidney and lung weights.
POCTA exerts antihypertensive effects together with vascular and hypertension target organ protection in SHR. Since interest in pomace olive oil has been low, the results of this study contribute to increasing awareness of its biological and nutritional values.