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mnfr2077-sup-0001-FigureS1.docx216KFigure S1. Effects of EGCG on thigmotactic behaviour in the visuo-spatial learning task in TgDyrk1A and Ts65Dn mouse models. (A, B) Percentage of time spent in the periphery (thigmotaxis) of the pool during the acquisition sessions in (A) TgDyrk1A and (B) Ts65Dn. Data are represented as mean ± SEM. Genotype effect ** p < 0.01, *** p < 0.001; treatment effect # p < 0.05, ## p < 0.01.
mnfr2077-sup-0002-TableS1.docx75KTable S1. CONSORT diagram
mnfr2077-sup-0003-TableS2.docx18KTable S2. Descriptive values for clinical and biochemical parameters at baseline and after three months of treatment
mnfr2077-sup-0004-TableS3.docx18KTable S3. Effect of EGCG treatment on neuropsychological performance after three months of administration
mnfr2077-sup-0005-TableS4.docx17KTable S4. Effect of EGCG treatment on functional ability, adaptive behaviour and quality of life outcomes after three months of administration
mnfr2077-sup-0006-TableS5.docx18KTable S5. Descriptive analysis on the qualitative data provided by parents at the end of the study period on blind guess of treatment assignment, presence or absence of relevant changes along the trial and nature of the changes observed.

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