REV-ERB-ALPHA circadian gene variant associates with obesity in two independent populations: Mediterranean and North American

Authors

  • Marta Garaulet,

    Corresponding author
    1. Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain
    2. Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    • Correspondence: Professor Marta Garaulet, Department of Physiology, Faculty of Biology, University of Murcia, Campus de Espinardo, s/n. 30100 Murcia, Spain

      E-mail: garaulet@um.es

      Fax: +34-868-88-39-63

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  • Caren E. Smith,

    1. Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
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  • Purificación Gomez-Abellán,

    1. Department of Physiology, Faculty of Biology, University of Murcia, Murcia, Spain
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  • María Ordovás-Montañés,

    1. Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
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  • Yu-Chi Lee,

    1. Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
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  • Laurence D. Parnell,

    1. Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
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  • Donna K. Arnett,

    1. Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA
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  • José M. Ordovás

    1. Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    2. Department of Epidemiology, Centro Nacional Investigaciones Cardiovasculares (CNIC), Madrid, Spain
    3. Instituto Madrileño de Estudios Avanzados en Alimentación (IMDEA-FOOD), Madrid, Spain
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Abstract

Scope

Despite the solid connection between REV-ERB and obesity, the information about whether genetic variations at this locus may be associated with obesity traits is scarce. Therefore our objective was to study the association between REV-ERB-ALPHA1 rs2314339 and obesity in two independent populations.

Methods and results

Participants were 2214 subjects from Spanish Mediterranean (n = 1404) and North American (n = 810) populations. Anthropometric, biochemical, dietary, and genotype analyses were performed. We found novel associations between the REV-ERB-ALPHA1 rs2314339 genotype and obesity in two independent populations: in Spanish Mediterranean and North American groups, the frequency of the minor-allele-carriers (AA+ AG) was significantly lower in the “abdominally obese” group than in those of the “nonabdominally obese” group (p < 0.05). Minor allele carriers had lower probability of abdominal obesity than noncarriers, and the effect was of similar magnitude for both populations (OR ≈ 1.50). There were consistent associations between REV-ERB-ALPHA1 genotype and obesity-related traits (p < 0.05). Energy intake was not significantly associated with REV-ERB-ALPHA1 rs2314339. However, physical activity significantly differed by genotype. A significant interaction between the REV-ERB-ALPHA1 variant and monounsaturated-fatty-acids (MUFA) intake for obesity was also detected in the Mediterranean population.

Conclusion

This new discovery highlights the importance of REV-ERB-ALPHA1 in obesity and provides evidence for the connection between our biological clock and obesity-related traits.

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