Long-term commercial cow's milk consumption and its effects on metabolic parameters associated with obesity in young mice
Article first published online: 23 DEC 2013
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecular Nutrition & Food Research
Volume 58, Issue 5, pages 1061–1068, May 2014
How to Cite
Yamin, H. B., Barnea, M., Genzer, Y., Chapnik, N. and Froy, O. (2014), Long-term commercial cow's milk consumption and its effects on metabolic parameters associated with obesity in young mice. Mol. Nutr. Food Res., 58: 1061–1068. doi: 10.1002/mnfr.201300650
- Issue published online: 22 APR 2014
- Article first published online: 23 DEC 2013
- Manuscript Accepted: 22 OCT 2013
- Manuscript Revised: 20 OCT 2013
- Manuscript Received: 5 SEP 2013
- Israeli Dairy Board. Grant Number: 3-00000-8325
- Fatty acid;
- Low fat;
Research has demonstrated that consumption of milk promotes weight loss and satiety, however conflicting evidence also exists. Therefore, we tested the effect of long-term milk consumption on body weight and metabolic parameters.
Methods and results
Newly weaned mice received whole milk, low-fat milk, or water as control for 17 weeks and serum, liver, and white adipose tissue (WAT) were tested for parameters associated with obesity and diabetes. Our results show that low-fat milk leads to the same overall caloric intake and body weight as the control group. However, the whole-milk group consumed more calories and reached a higher body weight. In addition, in the low-fat milk group, cholesterol, HDL-cholesterol, triglycerides, leptin, ghrelin, insulin, corticosterone, and glucagon were not significantly different than the control group. In contrast, in the whole-milk group, cholesterol, HDL-cholesterol, triglycerides, and glucagon were high compared with the control group. Metabolism in both liver and WAT showed only slight differences between the milk groups. Whereas the whole-milk group showed reduced insulin signaling in WAT, the low-fat milk group exhibited increased insulin signaling.
Whole-milk consumption leads to increased body weight and caloric intake and reduced insulin signaling in WAT, as opposed to low-fat milk consumption.