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Keywords:

  • transitional liver cell tumor;
  • hepatoblastoma;
  • hepatocellular carcinoma;
  • liver cell tumors;
  • beta-catenin;
  • pediatric liver tumors

Abstract

Background

We encountered on seven malignant hepatocellular tumors developing in older children and adolescents.

Results

These tumors exhibit an unusual phenotype with respect to clinical presentation, histopathology, immunohistochemistry, and treatment response. As a working hypothesis, we suggest that these apparently novel, unusual, and aggressive tumors occurring in older children and adolescents may form a transition in the putative developmental pathway of hepatocarcinogenesis.

Conclusion

We therefore propose the term, transitional liver cell tumors (TLCT), to denote these lesions. Med Pediatr Oncol 2002;39:510–518. © 2002 Wiley-Liss, Inc.