Transitional liver cell tumors (TLCT) in older children and adolescents: A novel group of aggressive hepatic tumors expressing beta-catenin
Version of Record online: 12 SEP 2002
Copyright © 2002 Wiley-Liss, Inc.
Medical and Pediatric Oncology
Special Issue: Proceedings of the Third SIOPEL Liver Tumour Study Group Workshop
Volume 39, Issue 5, pages 510–518, November 2002
How to Cite
Prokurat, A., Kluge, P., Kościesza, A., Perek, D., Kappeler, A. and Zimmermann, A. (2002), Transitional liver cell tumors (TLCT) in older children and adolescents: A novel group of aggressive hepatic tumors expressing beta-catenin. Med. Pediatr. Oncol., 39: 510–518. doi: 10.1002/mpo.10177
- Issue online: 12 SEP 2002
- Version of Record online: 12 SEP 2002
- transitional liver cell tumor;
- hepatocellular carcinoma;
- liver cell tumors;
- pediatric liver tumors
We encountered on seven malignant hepatocellular tumors developing in older children and adolescents.
These tumors exhibit an unusual phenotype with respect to clinical presentation, histopathology, immunohistochemistry, and treatment response. As a working hypothesis, we suggest that these apparently novel, unusual, and aggressive tumors occurring in older children and adolescents may form a transition in the putative developmental pathway of hepatocarcinogenesis.
We therefore propose the term, transitional liver cell tumors (TLCT), to denote these lesions. Med Pediatr Oncol 2002;39:510–518. © 2002 Wiley-Liss, Inc.