Presented at the 7th International Conference on the Long-Term Complications of Treatment of Children and Adolescents for Cancer.
Effect of glucocorticoids on bone density†
Version of Record online: 11 JUL 2003
Copyright © 2003 Wiley-Liss, Inc.
Medical and Pediatric Oncology
Volume 41, Issue 3, pages 212–216, September 2003
How to Cite
Rehman, Q. and Lane, N. E. (2003), Effect of glucocorticoids on bone density. Med. Pediatr. Oncol., 41: 212–216. doi: 10.1002/mpo.10339
- Issue online: 11 JUL 2003
- Version of Record online: 11 JUL 2003
- bone growth;
Glucocorticoid therapy is the most common cause of secondary iatrogenic osteoporosis. The bone loss occurs predominantly due to a decrease in bone formation, although increased bone resorption also occurs. Glucocorticoids induce osteoblast apoptosis and increase osteoclast survival and activity. Most of these effects are mediated through the RANKL-OPG system but perturbations in gonadal hormone activity and calcium balance may also contribute significantly to bone loss. Future therapies in the treatment and prevention of glucocorticoid-induced osteoporosis may be targeted at restoring the hormonal and cytokine balance to nullify the apoptotic effect of glucocorticoids on bone forming cells. Med Pediatr Oncol 2003;41:212–216. © 2003 Wiley-Liss, Inc.