Second primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood

Authors

  • Dr. Ann L. Hartley BSc, PhD,

    Corresponding author
    1. Cancer Research Campaign Paediatric and Familial Cancer Research Group, Department of Epidemiology and Social Oncology, Manchester, England
    • Cancer Research Campaign Paediatric and Familial Cancer Research Group, Department of Epidemiology and Social Oncology, Christie Hospital NHS Trust, Manchester, England
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  • Jillian M. Birch BSc, MSc, PhD,

    1. Cancer Research Campaign Paediatric and Familial Cancer Research Group, Department of Epidemiology and Social Oncology, Manchester, England
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  • Valerie Blair BA, MSc,

    1. Cancer Research Campaign Paediatric and Familial Cancer Research Group, Department of Epidemiology and Social Oncology, Manchester, England
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  • Patricia Morris Jones MB, BS, FRCP, DCH,

    1. Department of Child Health (Paediatric Oncology), Manchester, England
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  • H. Rao Gattamaneni MD, MB, BS, FRCR,

    1. Department of Radiotherapy, Christie Hospital NHS Trust, Manchester, England
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  • Anna M. Kelsey MRCS, LRCP, MRCPath

    1. Department of Pathology, Royal Manchester Children's Hospital, Pendlebury, Manchester, England
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Abstract

Eight second malignant tumours developed in a population-based series of 218 patients diagnosed with renal tumours in childhood: renal cell carcinoma of the contralateral kidney, hepatocellular carcinoma, Hodgkin's disease, and 4 basal cell and 1 squamous cell carcinomas of skin. Excess risk of developing a second malignancy (excluding skin carcinomas but including a registrable spinal neurofibroma) was 14.7 (95% Cl 4.0-37.7, P = 0.0003) for Wilms' tumour patients. Cumulative incidence of second malignant neoplasms (excluding skin carcinoma) was zero at 10 years, 5.0% at 20 years, and 10.2% at 30 years. The most common second neoplasms seen were benign osseous/chondromatous tumours and 4 of the 7 Wilms' tumour patients with malignant tumours had previous or synchronous tumours of this kind. Development of bony exostoses may be a marker for those patients at particularly high risk of subsequent malignancy. © 1994 wiley-Liss, Inc.

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