In situ breast carcinoma after treatment during adolescence for thyroid cancer with radioiodine

Authors

  • Daniel M. Green MD,

    Corresponding author
    1. Department of Pediatrics, University at Buffalo, State University of New York, Buffalo, New York
    2. Department of Surgical Oncology, Roswell Park Cancer Institute, and the Departments of Pediatric, University at Buffalo, State University of New York, Buffalo, New York
    • Department of Pediatrics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263
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  • Stephen B. Edge MD,

    1. Department of Surgery, University at Buffalo, State University of New York, Buffalo, New York
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  • Remedios B. Penetrante MD,

    1. Department of Pathology, University at Buffalo, State University of New York, Buffalo, New York
    2. Department of Pathology, University at Buffalo, State University of New York, Buffalo, New York
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  • Suraj Bakshi MD,

    1. Department of Nuclear Medicine, University at Buffalo, State University of New York, Buffalo, New York
    2. Department of Breast Surgery, University at Buffalo, State University of New York, Buffalo, New York
    3. Nuclear Medicine, University at Buffalo, State University of New York, Buffalo, New York
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  • Donald Shedd MD,

    1. Divisions of Head and Neck Surgery, University at Buffalo, State University of New York, Buffalo, New York
    2. Department of Surgery, University at Buffalo, State University of New York, Buffalo, New York
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  • Michael A. Zevon PhD

    1. Department of Psychology, University at Buffalo, State University of New York, Buffalo, New York
    2. Department of School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York
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Abstract

We reviewed the courses of patients treated during childhood or adolescence for thyroid cancer to estimate the frequency of, and to identify possible risk factors for, the occurrence of second malignant tumors in this population.

We identified all patients treated for thyroid cancer in a cohort of 1,406 pediatric cancer patients who were diagnosed prior to 20 years of age during the period January 1, 1960 through December 31, 1988 and who were treated at Roswell Park Cancer Institute.

Twelve patients were treated for thyroid cancer, of whom nine were women. In situ breast carcinoma was diagnosed 25 and 26 years after diagnosis of thyroid cancer in two of four women treated with radioiodine. No new cancers were diagnosed in the five women treated with thyroidectomy only.

Two of four women treated for thyroid cancer during adolescence with radioiodine, which is concentrated in the breast as well as other organs, developed in situ breast carcinoma. Review of a large cohort of adolescent female thyroid cancer patients treated with radioiodine is necessary to provide an accurate estimate of their risk of developing breast cancer. These patients must remain under medical surveillance throughout their lifetimes to facilitate prompt diagnosis of and early intervention for new conditions, such as the occurrence of breast cancer. © 1995 Wiley-Liss, Inc.

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