Review

Nuclear magnetic resonance coupled microseparations†

  1. A. G. Webb*

Article first published online: 27 JUL 2005

DOI: 10.1002/mrc.1616

Issue

Magnetic Resonance in Chemistry

Magnetic Resonance in Chemistry

Special Issue: Hyphenated NMR Techniques, Guest Editor: Professor Klaus Albert, University of Tübingen, Germany

Volume 43, Issue 9, pages 688–696, September 2005

Additional Information

How to Cite

Webb, A. G. (2005), Nuclear magnetic resonance coupled microseparations. Magnetic Resonance in Chemistry, 43: 688–696. doi: 10.1002/mrc.1616

Author Information

  1. Department of Electrical and Computer Engineering and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA

*Department of Electrical and Computer Engineering and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 N. Mathews, Urbana, Illinois 61801, USA.

  1. †

    Presented as part of a special issue on Hyphenated NMR Techniques

Publication History

  1. Issue published online: 27 JUL 2005
  2. Article first published online: 27 JUL 2005
  3. Manuscript Accepted: 12 APR 2005
  4. Manuscript Revised: 1 APR 2005
  5. Manuscript Received: 2 DEC 2004

Funded by

  • National Institutes of Health. Grant Number: EB002343.
  • National Science Foundation. Grant Number: DBI 97-22320.
  • Alexander von Humboldt Foundation (Wolfgang Paul Preis).

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Keywords:

  • NMR;
  • limits of detection;
  • microcoils;
  • microseparations;
  • capillary liquid chromatography;
  • capillary electrophoresis;
  • capillary isotachophoresis;
  • hyphenation

Abstract

The increased separation efficiency afforded by reducing the size of the separation column has resulted in ‘microseparations’ becoming an important component in many chemical and biochemical applications. The coupling of microseparations with NMR detection is an area of increasing interest owing to the high structural information of NMR. In order to couple efficiently with the separation, the NMR detector must be reduced in size to correspond to that of the separation peak. This paper summarizes some of the approaches used in coupling NMR detection with pressure-driven and electrophoretic microseparations, the design of small NMR detectors and applications of this technology. Copyright © 2005 John Wiley & Sons, Ltd.

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