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Fast multidimensional localized parallel NMR spectroscopy for the analysis of samples

  1. Marino Vega-Vazquez1,
  2. Juan Carlos Cobas2,
  3. Manuel Martin-Pastor1,*

Article first published online: 26 JUL 2010

DOI: 10.1002/mrc.2659

Issue

Magnetic Resonance in Chemistry

Magnetic Resonance in Chemistry

Volume 48, Issue 10, pages 749–752, October 2010

Additional Information

How to Cite

Vega-Vazquez, M., Cobas, J. C. and Martin-Pastor, M. (2010), Fast multidimensional localized parallel NMR spectroscopy for the analysis of samples. Magnetic Resonance in Chemistry, 48: 749–752. doi: 10.1002/mrc.2659

Author Information

  1. 1

    Unidad de Resonancia Magnética, RIAIDT, Edif. CACTUS, Campus Sur, Universidad de Santiago de Compostela, Santiago de Compostela, A Coruña 15706, Spain

  2. 2

    Mestrelab Research S. L., Feliciano Barrera 9B - Bajo, 15706 Santiago de Compostela, A Coruña 15706, Spain

*Unidad de Resonancia Magnética, RIAIDT, Edif. CACTUS, Campus Sur, Universidad de Santiago de Compostela, Santiago de Compostela, A Coruña 15706, Spain.

Publication History

  1. Issue published online: 16 SEP 2010
  2. Article first published online: 26 JUL 2010
  3. Manuscript Accepted: 30 JUN 2010
  4. Manuscript Revised: 20 JUN 2010
  5. Manuscript Received: 19 MAY 2010

Funded by

  • Xunta de Galicia. Grant Number: PGIDT05SIN012E

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Keywords:

  • NMR;
  • 1H;
  • fast-NMR;
  • localized spectroscopy;
  • localized COSY

Graphical Abstract

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A parallel localized spectroscopy (PALSY) method is presented to speed up the acquisition of multidimensional NMR spectra. The sample is virtually divided into a discrete number of nonoverlapping slices that relaxes independently during consecutive scans of the experiment. PALSY does not impose any limit in the achievable resolution in any dimension, uses conventional processing and once it is calibrated can be used routinely. The method was tested to acquire in parallel 2D COSY, 2D DQF-COSY and 2D TQF-COSY.

Abstract

A parallel localized spectroscopy (PALSY) method is presented to speed up the acquisition of multidimensional NMR (nD) spectra. The sample is virtually divided into a discrete number of nonoverlapping slices that relax independently during consecutive scans of the experiment, affording a substantial reduction in the interscan relaxation delay and the total experiment time. PALSY was tested for the acquisition of three experiments 2D COSY, 2D DQF-COSY and 2D TQF-COSY in parallel, affording a time-saving factor of 3–4. Some unique advantages are that the achievable resolution in any dimension is not compromised in any way: it uses conventional NMR data processing, it is not prone to generate spectral artifacts, and once calibrated, it can be used routinely with these and other combinations of NMR spectra. Copyright © 2010 John Wiley & Sons, Ltd.

View Full Article with Supporting Information (HTML) Get PDF (139K)