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1H and 13C NMR assignments of two new isomeric bisbenzylisoquinoline alkaloids from Cissampelos sympodialis Eichl. (Menispermaceae)


Correspondence to: José Maria Barbosa Filho, Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, CEP 58051-970, João Pessoa, PB, Brazil. E-mail:


des-7′-O-methylroraimine (compound 1) and epi-des-7′-O-methylroraimine (compound 2), two new isomeric bisbenzylisoquinoline alkaloids were isolated and characterized as a mixture from the rhizomes of Cissampelos sympodialis Eichl. The unambiguous structural elucidation of both isomers was performed with the aid of HR-ESI-MS, FT-IR, and NMR techniques including COSY, HMQC, HMBC, and NOESY. Copyright © 2013 John Wiley & Sons, Ltd.