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Keywords:

  • NMR;
  • HSQMBC;
  • E.COSY;
  • long-range proton–carbon coupling constants;
  • IPAP

Three different J-editing methods (IPAP, E.COSY and J-resolved) are implemented in a single NMR experiment to provide spin-state-edited 2D cross-peaks from which a simultaneous measurement of different homonuclear and heteronuclear coupling constants can be performed. A new J-selHSQMBC-IPAP experiment is proposed for the independent measurement of two different nJ(CH) coupling constants along the F2 and F1 dimensions of the same 2D cross-peak. In addition, the E.COSY pattern provides additional information about the magnitude and relative sign between J(HH) and nJ(CH) coupling constants. Copyright © 2013 John Wiley & Sons, Ltd.