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Structural studies of the chemical constituents of Tithonia tagetiflora Desv. (Asteraceae)

Authors


Correspondence to: Kim Phi Phung Nguyen, Department of Organic Chemistry, University of Science, Vietnam National University of Ho Chi Minh City, 227 Nguyen Van Cu Str., Dist. 5, Ho Chi Minh City, Vietnam. E-mail: kimphiphung@yahoo.fr

Abstract

Tithonia tagetiflora Desv. (Asteraceae) is a widespread plant in Vietnam, and the species of Tithonia are known as plants containing many biologically active compounds. However, T. tagetiflora's chemical composition remains mostly unknown. Therefore, we now report the structural elucidation of two new sesquiterpene lactones, 8-angeloyloxy-2,14-epoxygermacra-4,10(1),11(13)-trien-6,12-olide (1) and 6-angeloyloxy-1-hydroxy-3,4-epoxygermacra-9,11(13)-dien-8,12-olide (2), together with three known compounds, including two norisoprenoids, (6S,9S)-vomifoliol or (6R,9R)-vomifoliol (3) and (6S,9S)-roseoside (4), and one glutinane type triterpene, epi-glutinol (5), from the leaves of T. tagetiflora. Their structures are established by 1D and 2D NMR spectroscopy, as well as ESI-MS analysis and comparison with literature data. Copyright © 2013 John Wiley & Sons, Ltd.

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