On the interference of J(HH) modulation in HSQMBC-IPAP and HMBC-IPAP experiments
Article first published online: 18 JUN 2013
Copyright © 2013 John Wiley & Sons, Ltd.
Magnetic Resonance in Chemistry
Volume 51, Issue 9, pages 509–516, September 2013
How to Cite
Saurí, J. and Parella, T. (2013), On the interference of J(HH) modulation in HSQMBC-IPAP and HMBC-IPAP experiments. Magn. Reson. Chem., 51: 509–516. doi: 10.1002/mrc.3977
- Issue published online: 7 AUG 2013
- Article first published online: 18 JUN 2013
- Manuscript Accepted: 19 MAY 2013
- Manuscript Revised: 22 MAR 2013
- Manuscript Received: 23 JAN 2013
- proton–carbon coupling constants;
The effects of phase modulation due to homonuclear proton–proton coupling constants in HSQMBC-IPAP and HMBC-IPAP experiments are experimentally evaluated. We show that accurate values of small proton–carbon coupling constants, nJCH, can be extracted even for phase-distorted cross-peaks obtained from a selHSQMBC experiment applied simultaneously on two mutually J-coupled protons. On the other hand, an assessment of the reliability of nJCH measurement from distorted cross-peaks obtained in broadband IPAP versions of equivalent HMBC and HSQMBC experiments is also presented. Finally, we show that HMBC-COSY experiments could be an excellent complement to HMBC for the measurement of small nJCH values. Copyright © 2013 John Wiley & Sons, Ltd.