Gamete self-discrimination in ascidians: A role for the follicle cells
Article first published online: 4 FEB 2005
Copyright © 1991 Wiley-Liss, Inc.
Molecular Reproduction and Development
Volume 29, Issue 1, pages 47–50, May 1991
How to Cite
De Santis, R. and Pinto, M. R. (1991), Gamete self-discrimination in ascidians: A role for the follicle cells. Mol. Reprod. Dev., 29: 47–50. doi: 10.1002/mrd.1080290108
- Issue published online: 4 FEB 2005
- Article first published online: 4 FEB 2005
- Manuscript Accepted: 28 NOV 1990
- Manuscript Received: 15 SEP 1990
- Self-nonself recognition;
- Gamete self-recognition;
Gamete self-incompatibility in the hermaphrodite tunicate Ciona intestinalis is a useful system with which to study self-nonself recognition. We have used in vitro fertilization of oocytes isolated from the gonad of Ciona intestinalis to identify the cellular source of self-sterility elements present on the egg envelopes. Here we show for the first time that self-discrimination, which occurs on the egg vitelline coat, is established there in late oogenesis and is contributed or controlled by products of the overlying follicle cells. The acquisition of self-sterility by the oocyte is prevented by the ionophore monensin, which suggests that the follicle cell self-sterility controlling factor is a glycoprotein.