Distinct roles for distal-less genes Dlx3 and Dlx5 in regulating ectodermal development in Xenopus
Article first published online: 28 SEP 2001
Copyright © 2001 Wiley-Liss, Inc.
Molecular Reproduction and Development
Volume 60, Issue 3, pages 331–337, November 2001
How to Cite
Luo, T., Matsuo-Takasaki, M. and Sargent, T. D. (2001), Distinct roles for distal-less genes Dlx3 and Dlx5 in regulating ectodermal development in Xenopus. Mol. Reprod. Dev., 60: 331–337. doi: 10.1002/mrd.1095
- Issue published online: 28 SEP 2001
- Article first published online: 28 SEP 2001
- Manuscript Accepted: 22 MAY 2001
- Manuscript Received: 27 FEB 2001
- neural crest;
- neural plate;
In vertebrates, there are six or more copies of genes related to the Drosophila pattern formation homeodomain gene Distal-less. Among this family, Dlx3 and Dlx5 share extensive sequence homology and have similar, but distinctive, expression patterns, suggesting that these two factors may have substantially redundant developmental functions. Here we show that at the earliest phases of embryogenesis in Xenopus, there are significant differences between Dlx3 and Dlx5 expression and that this correlates with different functions in the restriction of neural crest and neural plate boundaries, respectively. Mol. Reprod. Dev. 60: 331–337, 2001. © 2001 Wiley-Liss, Inc.