Michael Harrington and Elim Hong contributed equally to this work.
Comparative analysis of neurulation: First impressions do not count†
Article first published online: 3 AUG 2009
Copyright © 2009 Wiley-Liss, Inc.
Molecular Reproduction and Development
Special Issue: In Honor of E.E. Just
Volume 76, Issue 10, pages 954–965, October 2009
How to Cite
Harrington, M. J., Hong, E. and Brewster, R. (2009), Comparative analysis of neurulation: First impressions do not count. Mol. Reprod. Dev., 76: 954–965. doi: 10.1002/mrd.21085
- Issue published online: 19 AUG 2009
- Article first published online: 3 AUG 2009
- Manuscript Accepted: 15 JUN 2009
- Manuscript Received: 12 MAR 2009
The central nervous system of vertebrate embryos originates from the neural tube (NT), a simple epithelium surrounding a central lumen. The mechanisms underlying the shaping of the NT, a process otherwise known as neurulation, have been the focus of numerous studies, using a variety of model systems. Yet, it remains unclear to what extent neurulation is conserved across vertebrates. This review provides a comparison between modes of neurulation, with a focus on cellular mechanisms. An emerging concept is that cell behaviors reveal similarities between modes of neurulation that cannot be predicted from morphological comparisons. Mol. Reprod. Dev. 76: 954–965, 2009. © 2009 Wiley-Liss, Inc.