Cell plasticity in homeostasis and regeneration
Version of Record online: 2 JUL 2010
Copyright © 2010 Wiley-Liss, Inc.
Molecular Reproduction and Development
Volume 77, Issue 10, pages 837–855, October 2010
How to Cite
Galliot, B. and Ghila, L. (2010), Cell plasticity in homeostasis and regeneration. Mol. Reprod. Dev., 77: 837–855. doi: 10.1002/mrd.21206
- Issue online: 2 JUL 2010
- Version of Record online: 2 JUL 2010
- Manuscript Accepted: 1 MAY 2010
- Manuscript Received: 10 DEC 2009
Over the past decades, genetic analyses performed in vertebrate and invertebrate organisms deciphered numerous cellular and molecular mechanisms deployed during sexual development and identified genetic circuitries largely shared among bilaterians. In contrast, the functional analysis of the mechanisms that support regenerative processes in species randomly scattered among the animal kingdom, were limited by the lack of genetic tools. Consequently, unifying principles explaining how stress and injury can lead to the reactivation of a complete developmental program with restoration of original shape and function remained beyond reach of understanding. Recent data on cell plasticity suggest that beside the classical developmental approach, the analysis of homeostasis and asexual reproduction in adult organisms provides novel entry points to dissect the regenerative potential of a given species, a given organ or a given tissue. As a clue, both tissue homeostasis and regeneration dynamics rely on the availability of stem cells and/or on the plasticity of differentiated cells to replenish the missing structure. The freshwater Hydra polyp provides us with a unique model system to study the intricate relationships between the mechanisms that regulate the maintenance of homeostasis, even in extreme conditions (starvation and overfeeding) and the reactivation of developmental programs after bisection or during budding. Interestingly head regeneration in Hydra can follow several routes according to the level of amputation, suggesting that indeed the homeostatic background dramatically influences the route taken to bridge injury and regeneration. Mol. Reprod. Dev. 77:837–855, 2010. © 2010 Wiley-Liss, Inc.