Improvements in methods to generate such swine has led to an expansive growth in the number of pig models specifically developed to enhance human health and nutrition.
Genetic modifications of pigs for medicine and agriculture†
Article first published online: 10 JUN 2011
Copyright © 2011 Wiley Periodicals, Inc.
Molecular Reproduction and Development
Special Issue: From Sea to Land at The Friday Harbor Laboratories
Volume 78, Issue 10-11, pages 879–891, October - November 2011
How to Cite
Whyte, J. J. and Prather, R. S. (2011), Genetic modifications of pigs for medicine and agriculture. Mol. Reprod. Dev., 78: 879–891. doi: 10.1002/mrd.21333
- Issue published online: 17 OCT 2011
- Article first published online: 10 JUN 2011
- Manuscript Accepted: 9 MAY 2011
- Manuscript Received: 21 MAR 2011
- National Institutes of Health. Grant Numbers: R01 RR13438, U42 RR018877, R21 NS59510, P01 HL51670, U01 HL102288
- Food for the 21st Century (University of Missouri)
Genetically modified swine hold great promise in the fields of agriculture and medicine. Currently, these swine are being used to optimize production of quality meat, to improve our understanding of the biology of disease resistance, and to reduced waste. In the field of biomedicine, swine are anatomically and physiologically analogous to humans. Alterations of key swine genes in disease pathways provide model animals to improve our understanding of the causes and potential treatments of many human genetic disorders. The completed sequencing of the swine genome will significantly enhance the specificity of genetic modifications, and allow for more accurate representations of human disease based on syntenic genes between the two species. Improvements in both methods of gene alteration and efficiency of model animal production are key to enabling routine use of these swine models in medicine and agriculture. Mol. Reprod. Dev. 78:879–891, 2011. © 2011 Wiley Periodicals, Inc.