Systematic review of chorioamnionitis and cerebral palsy

Authors

  • Yvonne W. Wu

    Corresponding author
    1. Departments of Neurology and Pediatrics, University of California at San Francisco, San Francisco, California
    • Departments of Pediatrics and Neurology, University of California at San Francisco, Box 0136, San Francisco, CA 94143-0136
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Abstract

In a recent meta-analysis evaluating the relationship between chorioamnionitis and cerebral palsy, we found that chorioamnionitis is a risk factor for both cerebral palsy and cystic periventricular leukomalacia (cPVL). The current paper extends the meta-analysis by including studies published in the year 2000, and by further evaluating the causes of heterogeneity among individual study results. Using a random effects model, clinical chorioamnionitis was significantly associated with both cerebral palsy (RR 1.9, 95% CI 1.5–2.5) and cPVL (RR 2.6, 95% CI 1.7–3.9). Sources of heterogeneity included widely varying practices in the diagnosis of clinical chorioamnionitis, different gestational age characteristics, and varying study year. We conclude that based on the available literature, chorioamnionitis is a risk factor for both cerebral palsy and cPVL. MRDD Research Reviews 2002;8:25–29. © 2002 Wiley-Liss, Inc.

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