Systematic review of chorioamnionitis and cerebral palsy
Article first published online: 28 FEB 2002
Copyright © 2002 Wiley-Liss, Inc.
Mental Retardation and Developmental Disabilities Research Reviews
Volume 8, Issue 1, pages 25–29, 2002
How to Cite
Wu, Y. W. (2002), Systematic review of chorioamnionitis and cerebral palsy. Ment. Retard. Dev. Disabil. Res. Rev., 8: 25–29. doi: 10.1002/mrdd.10003
- Issue published online: 28 FEB 2002
- Article first published online: 28 FEB 2002
- Manuscript Accepted: 12 OCT 2001
- Manuscript Received: 17 SEP 2001
- NSADA. Grant Number: 5 K12 NS01692-05
- cerebral palsy;
- cystic periventricular leukomalacia;
In a recent meta-analysis evaluating the relationship between chorioamnionitis and cerebral palsy, we found that chorioamnionitis is a risk factor for both cerebral palsy and cystic periventricular leukomalacia (cPVL). The current paper extends the meta-analysis by including studies published in the year 2000, and by further evaluating the causes of heterogeneity among individual study results. Using a random effects model, clinical chorioamnionitis was significantly associated with both cerebral palsy (RR 1.9, 95% CI 1.5–2.5) and cPVL (RR 2.6, 95% CI 1.7–3.9). Sources of heterogeneity included widely varying practices in the diagnosis of clinical chorioamnionitis, different gestational age characteristics, and varying study year. We conclude that based on the available literature, chorioamnionitis is a risk factor for both cerebral palsy and cPVL. MRDD Research Reviews 2002;8:25–29. © 2002 Wiley-Liss, Inc.