The first author is partially supported by a grant to the J. F. Kennedy Center Vanderbilt University (HD5052).
Identifying predictors of treatment response
Version of Record online: 20 DEC 2004
Copyright © 2004 Wiley-Liss, Inc.
Mental Retardation and Developmental Disabilities Research Reviews
Special Issue: Treatment Efficacy
Volume 10, Issue 3, pages 162–168, August 2004
How to Cite
Yoder, P. and Compton, D. (2004), Identifying predictors of treatment response. Ment. Retard. Dev. Disabil. Res. Rev., 10: 162–168. doi: 10.1002/mrdd.20013
- Issue online: 20 DEC 2004
- Version of Record online: 20 DEC 2004
- Manuscript Accepted: 18 JUN 2004
- Manuscript Received: 26 MAY 2004
- J. F. Kennedy Center Vanderbilt University. Grant Number: HD5052
- research methodology;
- predictors of treatment response
This article provides a rationale for considering predictors of growth in a treatment group as inadequate to identifying predictors of treatment response. When we interpret predictors of growth in a treatment group as synonymous with predictors of treatment response, we implicitly attribute all of the treated children's growth to the treatment, an untenable assumption under most conditions. We also contend that the use of standard scores in predictors of growth studies does not allow us to differentiate growth from treatment, from growth from other factors. We present two research methodologies that are appropriate methods of identifying predictors of treatment response: (a) single-subject experimental logic utilized to identify the specific participants in which treatment responses (not just growth) were found, combined with follow-up group comparison logic to identify the characteristics on which responders and nonresponders differ, and (b) statistical interactions among child/family/context characteristics and randomly assigned group membership. Principles for selecting potential predictors of treatment response are provided. © 2004 Wiley-Liss, Inc. MRDD Research Reviews 2004;10:162–168.