Also affiliated with the School of Pharmacy, SBMU, Tehran, Iran.
Using mouse models to explore genotype–phenotype relationship in Down syndrome†
Article first published online: 1 OCT 2007
Copyright © 2007 Wiley-Liss, Inc.
Mental Retardation and Developmental Disabilities Research Reviews
Special Issue: Special Issue on Down Syndrome
Volume 13, Issue 3, pages 207–214, 2007
How to Cite
Salehi, A., Faizi, M., Belichenko, P. V. and Mobley, W. C. (2007), Using mouse models to explore genotype–phenotype relationship in Down syndrome. Ment. Retard. Dev. Disabil. Res. Rev., 13: 207–214. doi: 10.1002/mrdd.20164
This Review is dedicated to the memory of Dr. J. D. Delcroix, our former colleague who played an instrumental role in driving the research on the role of NGF signaling in Down syndrome and recently passed away due to unexpected medical complications. His intelligence, friendship, and dedication to research will remain with us forever.
- Issue published online: 1 OCT 2007
- Article first published online: 1 OCT 2007
- Manuscript Accepted: 13 AUG 2007
- Manuscript Received: 10 AUG 2007
- Alzheimer Association
- State of California Alzheimer's Program
- Down Syndrome Research and Treatment Foundation
- Larry L. Hillblom Foundation
- Thrasher Foundation
- NIA. Grant Number: AG16999
- NINDS. Grant Numbers: NS38869, NS055371
- Down syndrome;
- Alzheimer's disease;
Down Syndrome (DS) caused by trisomy 21 is characterized by a variety of phenotypes and involves multiple organs. Sequencing of human chromosome 21 (HSA21) and subsequently of its orthologues on mouse chromosome 16 have created an unprecedented opportunity to explore the complex relationship between various DS phenotypes and the extra copy of ∼300 genes on HSA21. Advances in genetics together with the ability to generate genetically well-defined mouse models have been instrumental in understanding the relationships between genotype and phenotype in DS. Indeed, elucidation of these relationships will play an important role in understanding the pathophysiological basis of this disorder and helping to develop therapeutic interventions. A successful example of using such a strategy is our recent studies exploring the relationship between failed nerve growth factor (NGF) transport and amyloid precursor protein (App) overexpression. We found that increased dosage of the gene for App is linked to failed NGF signaling and cholinergic neurodegeneration in a mouse model of DS. Herein, we discuss several mouse models of DS and explore the emergence of exciting new insights into genotype–phenotype relationships, particularly those related to nervous system abnormalities. An important conclusion is that uncovering these relationships is enhanced by working from carefully defined phenotypes to the genes responsible. © 2007 Wiley-Liss, Inc. MRDD Research Reviews 2007;13:207–214.