Production of PMMA Nanoparticles Loaded with Praziquantel Through “In Situ” Miniemulsion Polymerization

Authors

  • Laís B. Fonseca,

    1. Programa de Engenharia Química/COPPE Universidade Federal do Rio de Janeiro, Cidade Universitária, CP 68502 Rio de Janeiro, 21941-972 RJ, Brazil
    2. Farmanguinhos, FIOCRUZ Av. Comandante Guaranys 447, Jacarepaguá Rio de Janeiro, 22775-903 RJ, Brazil
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  • Márcio Nele,

    1. Programa de Engenharia Química/COPPE Universidade Federal do Rio de Janeiro, Cidade Universitária, CP 68502 Rio de Janeiro, 21941-972 RJ, Brazil
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  • Nádia Maria Volpato,

    1. Faculdade de Farmácia Universidade Federal do Rio Grande do Sul Av. Ipiranga 2752, Bairro Azenha Porto Alegre, 90610-000 RS, Brazil
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  • Rafael C. Seiceira,

    1. Farmanguinhos, FIOCRUZ Av. Comandante Guaranys 447, Jacarepaguá Rio de Janeiro, 22775-903 RJ, Brazil
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  • José Carlos Pinto

    Corresponding author
    1. Programa de Engenharia Química/COPPE Universidade Federal do Rio de Janeiro, Cidade Universitária, CP 68502 Rio de Janeiro, 21941-972 RJ, Brazil
    • Programa de Engenharia Química/COPPE Universidade Federal do Rio de Janeiro, Cidade Universitária, CP 68502 Rio de Janeiro, 21941-972 RJ, Brazil
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Abstract

PZQ is the primary drug for treatment of schistosomiasis, but its efficiency is severely affected by its bitter taste. The main objective of this paper is the preparation of PMMA nanoparticles loaded with PZQ through in situ miniemulsion polymerizations and intended for oral formulations. Polymerizations are performed with an ultra turrax and a high-pressure homogenizer. Obtained nanoparticles are analyzed by DSC, HPLC, DLS, GC, SEM, and PZQ dissolution profiles. Obtained results indicate the successful encapsulation of PZQ in all runs. Obtained data also show that the high-pressure homogenizer leads to the best performance, allowing for preparation of stable latexes, with narrower particle size distributions and higher encapsulation efficiencies.

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