Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking

Authors

  • Susumu Mori,

    Corresponding author
    1. Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
    2. Kennedy Krieger Institute, Baltimore, Maryland
    3. F.M. Kirby Research Center for Functional Brain Imaging, Baltimore, Maryland
    • Dept. of Radiology, Johns Hopkins University School of Medicine, 217 Traylor Bldg., 720 Rutland Ave., Baltimore, MD 21205
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  • Walter E. Kaufmann,

    1. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    2. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    3. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland
    4. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
    5. Kennedy Krieger Institute, Baltimore, Maryland
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  • Christos Davatzikos,

    1. Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • Bram Stieltjes,

    1. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
    2. F.M. Kirby Research Center for Functional Brain Imaging, Baltimore, Maryland
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  • Laura Amodei,

    1. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • Kim Fredericksen,

    1. Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • Godfrey D. Pearlson,

    1. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • Elias R. Melhem,

    1. Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • Meiyappan Solaiyappan,

    1. Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
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  • Gerald V. Raymond,

    1. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    2. Kennedy Krieger Institute, Baltimore, Maryland
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  • Hugo W. Moser,

    1. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    2. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland
    3. Kennedy Krieger Institute, Baltimore, Maryland
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  • Peter C.M. van Zijl

    1. Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
    2. F.M. Kirby Research Center for Functional Brain Imaging, Baltimore, Maryland
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Abstract

Diffusion-tensor fiber tracking was used to identify the cores of several long-association fibers, including the anterior (ATR) and posterior (PTR) thalamic radiations, and the uncinate (UNC), superior longitudinal (SLF), inferior longitudinal (ILF), and inferior fronto-occipital (IFO) fasciculi. Tracking results were compared to existing anatomical knowledge, and showed good qualitative agreement. Guidelines were developed to reproducibly track these fibers in vivo. The interindividual variability of these reconstructions was assessed in a common spatial reference frame (Talairach space) using probabilistic mapping. As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X-linked adrenoleukodystrophy) was demonstrated. Magn Reson Med 47:215–223, 2002. © 2002 Wiley-Liss, Inc.

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