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Communication
Anisotropy in high angular resolution diffusion-weighted MRI †
Article first published online: 23 MAY 2001
DOI: 10.1002/mrm.1125
Published 2001 John Wiley & Sons, Inc.
Additional Information
How to Cite
Frank, L. R. (2001), Anisotropy in high angular resolution diffusion-weighted MRI . Magn Reson Med, 45: 935–939. doi: 10.1002/mrm.1125
- †
Publication History
- Issue published online: 23 MAY 2001
- Article first published online: 23 MAY 2001
- Manuscript Accepted: 5 FEB 2001
- Manuscript Revised: 21 DEC 2000
- Manuscript Received: 5 JUL 2000
Funded by
- VA. Grant Number: SA-321
- Abstract
- Article
- References
- Cited By
Keywords:
- diffusion;
- anisotropy;
- spherical diffusion variance;
- high angular resolution;
- white matter
Abstract
The diffusion in voxels with multidirectional fibers can be quite complicated and not necessarily well characterized by the standard diffusion tensor model. High angular resolution diffusion-weighted acquisitions have recently been proposed as a method to investigate such voxels, but the reconstruction methods proposed require sophisticated estimation schemes. We present here a simple algorithm for the identification of diffusion anisotropy based upon the variance of the estimated apparent diffusion coefficient (ADC) as a function of measurement direction. The rationale for this method is discussed, and results in normal human subjects acquired with a novel diffusion-weighted stimulated-echo spiral acquisition are presented which distinguish areas of anisotropy that are not apparent in the relative anisotropy maps derived from the standard diffusion tensor model. Magn Reson Med 45:935–939, 2001. Published 2001 Wiley-Liss, Inc.