Diffusion tensor imaging of the developing mouse brain

Authors

  • Susumu Mori,

    Corresponding author
    1. Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
    2. Kennedy Krieger Institute, F.M. Kirby Research Center for Functional Brain Imaging, Baltimore, Maryland
    • Johns Hopkins University School of Medicine, Department of Radiology, 217 Traylor Bldg., 720 Rutland Ave., Baltimore, MD 21205
    Search for more papers by this author
  • Ryuta Itoh,

    1. Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
    2. Shiga University of Medical Science, Ohtsu, Japan
    Search for more papers by this author
  • Jiangyang Zhang,

    1. Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
    2. Department of Medical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Search for more papers by this author
  • Walter E. Kaufmann,

    1. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    2. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
    3. Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland
    4. Kennedy Krieger Institute, F.M. Kirby Research Center for Functional Brain Imaging, Baltimore, Maryland
    Search for more papers by this author
  • Peter C.M. van Zijl,

    1. Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
    2. Kennedy Krieger Institute, F.M. Kirby Research Center for Functional Brain Imaging, Baltimore, Maryland
    Search for more papers by this author
  • Meiyappan Solaiyappan,

    1. Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Search for more papers by this author
  • Paul Yarowsky

    1. University of Maryland School of Medicine, Department of Pharmacology, Baltimore, Maryland
    Search for more papers by this author

Abstract

It is shown that diffusion tensor MR imaging (DTI) can discretely delineate the microstructure of white matter and gray matter in embryonic and early postnatal mouse brains based on the existence and orientation of ordered structures. This order was found not only in white matter but also in the cortical plate and the periventricular zone, which are precursors of the cerebral cortex. This DTI-based information could be used to accomplish the automated spatial definition of the cortical plate and various axonal tracts. The DTI studies also revealed a characteristic evolution of diffusion anisotropy in the cortex of the developing brain. This ability to detect changes in the organization of the brain during development will greatly enhance morphological studies of transgenic and knockout models of cortical dysfunction. Magn Reson Med 46:18–23, 2001. © 2001 Wiley-Liss, Inc.

Ancillary