Article

Quantitative NMR measurements of hippocampal atrophy in Alzheimer's disease

  1. J. P. Seab1,2,
  2. W. J. Jagust1,2,
  3. S. T. S. Wong1,
  4. M. S. Roos1,
  5. B. R. Reed2,
  6. T. F. Budinger1

Article first published online: 18 NOV 2005

DOI: 10.1002/mrm.1910080210

Issue

Magnetic Resonance in Medicine

Magnetic Resonance in Medicine

Volume 8, Issue 2, pages 200–208, October 1988

Additional Information

How to Cite

Seab, J. P., Jagust, W. J., Wong, S. T. S., Roos, M. S., Reed, B. R. and Budinger, T. F. (1988), Quantitative NMR measurements of hippocampal atrophy in Alzheimer's disease. Magn Reson Med, 8: 200–208. doi: 10.1002/mrm.1910080210

Author Information

  1. 1

    Donner Laboratory, Lawrence Berkeley Laboratory, University of California, Berkeley, California 94720

  2. 2

    Department of Neurology, Veterans Administration Medical Center, Martinez, California; and Department of Neurology, School of Medicine, University of California, Davis, California 95616

Publication History

  1. Issue published online: 18 NOV 2005
  2. Article first published online: 18 NOV 2005
  3. Manuscript Received: 16 FEB 1988

Funded by

  • NIH. Grant Number: AGO5890
  • National Institute on Aging, by the Medical Research Service of the United States Veterans Administration
  • Director, Office of Energy Research, Office of Health and Environmental Research of the United States Department of Energy. Grant Number: DE-AC03-76SF00098

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Abstract

Nuclear magnetic resonance (NMR) imaging was employed to study 10 patients with Alzheimer's disease (AD) and seven healthy elderly control subjects. Coronal sections were used to make volumetric measurements of the hippocampus, ventricles, subarach-noid space, and brain parenchyma. The hippocampal volume (normalized relative to the size of the lenticular nucleus) was reduced by 40% in the AD group compared to the controls, with no overlap between the two groups. Overall measures of brain atrophy and ventricular and sulcal enlargement also showed significantly different group means, although with overlap between the two groups. Hippocampal atrophy did not correlate with either overall brain atrophy or dementia severity, although the degree of brain atro-phy was correlated with dementia severity. These results show that NMR is capable of providing in vivo quantification of diminished hippocampal size in AD which is not cor-related with overall brain atrophy and which may differentiate AD from normal aging. © 1988 Academic Press, Inc.

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