Noninvasive temperature imaging using diffusion MRI

Authors

  • J. Delannoy,

    1. Biomedical Engineering and Instrumentation Program, Division of Research Services, Bethesda, Maryland 20892
    2. Radiation Oncology Branch/COP/DCT, National Cancer Institute, Bethesda, Maryland 20892
    Current affiliation:
    1. Sonotron-Hitachi, 91967, Les Ulis, France
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  • Ching-Nien Chen,

    1. Biomedical Engineering and Instrumentation Program, Division of Research Services, Bethesda, Maryland 20892
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  • R. Turner,

    1. Biomedical Engineering and Instrumentation Program, Division of Research Services, Bethesda, Maryland 20892
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  • R. L. Levin,

    1. Biomedical Engineering and Instrumentation Program, Division of Research Services, Bethesda, Maryland 20892
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  • D. Le Bihan

    1. Diagnostic Radiology Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892
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  • Presented at SMRM Workshop on Future Directions in MRI Diffusion and Microcirculation, Bethesda, MD, June 7 and 8, 1990.

Abstract

Efficacy and safety considerations for cancer therapy with hyperthermia require accurate temperature measurements throughout the heated volume. We report the use of molecular diffusion, whose temperature dependence is well known. A dedicated hyperthermia applicator was built, combining a MRI gradient coil and a rf coil. Diffusion and derived temperature images were obtained with a 1 × 2 mm pixel size on a polyacrylamide gel phantom using a clinical 1.5-T whole body MRI system. Temperatures determined from these images using 1 cm2 regions of interest were found to be within 0.2° of those recorded from the thermocouples and fiber-optic probes placed inside the gel. © 1991 Academic Press, Inc.

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