A one-dimensional velocity technique for NMR measurement of aortic distensibility

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Abstract

A technique is presented for rapidly and noninvasively determining aortic distensibility, by NMR measurement of wave velocity in the aorta. A two–dimensional NMR selective-excitation pulse is used to repeatedly excite a cylinder of magnetization in the aorta, with magnetization read out along the cylinder axis each time. A toggled bipolar flow-encoding pulse is applied prior to readout, to produce a one-dimensional phase-contrast flow image. Cardiac gating and data interleaving are employed to improve the effective time resolution to 2 ms. Wave velocities are determined from the slope of the leading edge of flow measured on the resulting M-mode velocity image. The technique is sensitive over a range of distensibilities from 10−8 to 10−3 m s2/kg. The average value in the descending thoracic aorta in seven normal subjects was found to be 4.8 × 10−5 m s2/kg, with a significant inverse correlation with age.

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