Full Paper

Evaluation of MRI for in vivo monitoring of retinal damage and detachment in experimental ocular inflammation

  1. Laura Pop-Fanea1,2,
  2. Sonia Nielles Vallespin1,
  3. James M. S. Hutchison1,
  4. John V. Forrester2,
  5. Hugh C. Seton1,
  6. Margaret A. Foster1,
  7. Janet Liversidge2,*

Article first published online: 22 DEC 2004

DOI: 10.1002/mrm.20326

Issue

Magnetic Resonance in Medicine

Magnetic Resonance in Medicine

Volume 53, Issue 1, pages 61–68, January 2005

Additional Information

How to Cite

Pop-Fanea, L., Vallespin, S. N., Hutchison, J. M. S., Forrester, J. V., Seton, H. C., Foster, M. A. and Liversidge, J. (2005), Evaluation of MRI for in vivo monitoring of retinal damage and detachment in experimental ocular inflammation. Magnetic Resonance in Medicine, 53: 61–68. doi: 10.1002/mrm.20326

Author Information

  1. 1

    Department of Biomedical Physics & Bioengineering, University of Aberdeen, Aberdeen, UK

  2. 2

    Department of Ophthalmology, University of Aberdeen, Aberdeen, UK

*Department of Ophthalmology, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom

Publication History

  1. Issue published online: 22 DEC 2004
  2. Article first published online: 22 DEC 2004
  3. Manuscript Revised: 14 JUL 2004
  4. Manuscript Accepted: 14 JUL 2004
  5. Manuscript Received: 24 NOV 2003

Funded by

  • Cunningham Trust UK. Grant Number: 00/8

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Keywords:

  • ocular MRI;
  • surface coil;
  • retinal detachment;
  • inflammatory autoimmune eye disease

Abstract

Two quantitative methods were developed for investigation of the potential of MRI for in vivo monitoring of retinal damage and detachment in experimental autoimmune uveitis (EAU). Measurements of retinal thickness and detachment area were performed on matched MR and histologic (HIST) images of rat eyes at different stages of EAU. In vivo MR images of rat eyes were acquired at 4.7 T using a figure-of-eight surface coil and a spin echo pulse sequence. Ex vivo measurements were performed on HIST images acquired using a digital camera attached to a microscope. MR images mirrored the HIST appearance of inflamed eyes at each stage of disease. Retinal detachments as small as 0.1 mm2 were measured in vivo by MRI and confirmed in the same eye ex vivo by histology. Measurements performed on corresponding MR and HIST images demonstrated a good agreement between the two techniques. The potential of MRI for in vivo visualization and for monitoring changes in the eye during development of EAU was demonstrated in this study. Magn Reson Med 53:61–68, 2005. © 2004 Wiley-Liss, Inc.

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