T1, T2 relaxation and magnetization transfer in tissue at 3T

Authors

  • Greg J. Stanisz,

    Corresponding author
    1. Imaging Research, Sunnybrook & Women's College Health Sciences Centre, Toronto, ON, Canada
    2. Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    • Imaging Research, Sunnybrook & Women's College Health Sciences Centre, S655–2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
    Search for more papers by this author
  • Ewa E. Odrobina,

    1. Imaging Research, Sunnybrook & Women's College Health Sciences Centre, Toronto, ON, Canada
    Search for more papers by this author
  • Joseph Pun,

    1. Imaging Research, Sunnybrook & Women's College Health Sciences Centre, Toronto, ON, Canada
    Search for more papers by this author
  • Michael Escaravage,

    1. Imaging Research, Sunnybrook & Women's College Health Sciences Centre, Toronto, ON, Canada
    Search for more papers by this author
  • Simon J. Graham,

    1. Imaging Research, Sunnybrook & Women's College Health Sciences Centre, Toronto, ON, Canada
    2. Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    Search for more papers by this author
  • Michael J. Bronskill,

    1. Imaging Research, Sunnybrook & Women's College Health Sciences Centre, Toronto, ON, Canada
    2. Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    Search for more papers by this author
  • R. Mark Henkelman

    1. Imaging Research, Sunnybrook & Women's College Health Sciences Centre, Toronto, ON, Canada
    2. Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    3. Mouse Imaging Centre (MICe), Hospital for Sick Children, Toronto, ON, Canada
    Search for more papers by this author

Abstract

T1, T2, and magnetization transfer (MT) measurements were performed in vitro at 3 T and 37°C on a variety of tissues: mouse liver, muscle, and heart; rat spinal cord and kidney; bovine optic nerve, cartilage, and white and gray matter; and human blood. The MR parameters were compared to those at 1.5 T. As expected, the T2 relaxation time constants and quantitative MT parameters (MT exchange rate, R, macromolecular pool fraction, M0B, and macromolecular T2 relaxation time, T2B) at 3 T were similar to those at 1.5 T. The T1 relaxation time values, however, for all measured tissues increased significantly with field strength. Consequently, the phenomenological MT parameter, magnetization transfer ratio, MTR, was lower by approximately 2 to 10%. Collectively, these results provide a useful reference for optimization of pulse sequence parameters for MRI at 3 T. Magn Reson Med, 2005. © 2005 Wiley-Liss, Inc.

Ancillary