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How to investigate oxygen supply, uptake, and utilization simultaneously by interleaved NMR imaging and spectroscopy of the skeletal muscle

  1. P. G Carlier1,*,
  2. C. Brillault-Salvat2,
  3. E. Giacomini2,
  4. C. Wary1,
  5. G. Bloch1

Article first published online: 9 SEP 2005

DOI: 10.1002/mrm.20649

Issue

Magnetic Resonance in Medicine

Magnetic Resonance in Medicine

Volume 54, Issue 4, pages 1010–1013, October 2005

Additional Information

How to Cite

Carlier, P. G., Brillault-Salvat, C., Giacomini, E., Wary, C. and Bloch, G. (2005), How to investigate oxygen supply, uptake, and utilization simultaneously by interleaved NMR imaging and spectroscopy of the skeletal muscle. Magnetic Resonance in Medicine, 54: 1010–1013. doi: 10.1002/mrm.20649

Author Information

  1. 1

    NMR Laboratory, AFM and CEA, Institute of Myology, Pitié-Salpêtrière University Hospital, IFR14, Paris, France

  2. 2

    SHFJ, CEA, Orsay, France

*NMR Laboratory, AFM and CEA, Institute of Myology, Bldg Babinski, Pitié-Salpêtrière University Hospital, 83, Bd de l'Hôpital, 75651 Paris Cedex 13, France

Publication History

  1. Issue published online: 26 SEP 2005
  2. Article first published online: 9 SEP 2005
  3. Manuscript Accepted: 26 MAY 2005
  4. Manuscript Revised: 23 MAY 2005
  5. Manuscript Received: 12 OCT 2004

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Keywords:

  • oxygen;
  • perfusion;
  • myoglobin;
  • skeletal muscle

Abstract

Human skeletal muscle perfusion, oxygenation, and high-energy phosphate distribution were measured simultaneously by interleaved 1H and 31P NMR spectroscopy and 1H NMR imaging in vivo. From these parameters, arterial oxygen supply (DO2), muscle reoxygenation rate, mitochondrial ATP production, and O2 consumption (VO2) were deduced at the recovery phase of a short ischemic exercise bout. In addition, by using a reformulation of the mass conservation law, muscle maximum O2 extraction was calculated from these parameters. Magn Reson Med, 2005. © 2005 Wiley-Liss, Inc.

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