This article is a US Government work and, as such, is in the public domain in the United States of America.
BOLD and CBV-weighted functional magnetic resonance imaging of the rat somatosensory system†
Article first published online: 21 DEC 2005
Published 2005 Wiley-Liss, Inc.
Magnetic Resonance in Medicine
Volume 55, Issue 2, pages 316–324, February 2006
How to Cite
Keilholz, S. D., Silva, A. C., Raman, M., Merkle, H. and Koretsky, A. P. (2006), BOLD and CBV-weighted functional magnetic resonance imaging of the rat somatosensory system. Magn Reson Med, 55: 316–324. doi: 10.1002/mrm.20744
- Issue published online: 26 JAN 2006
- Article first published online: 21 DEC 2005
- Manuscript Accepted: 31 AUG 2005
- Manuscript Revised: 24 AUG 2005
- Manuscript Received: 8 MAR 2005
- NIH, NINDS intramural research program
- cerebral blood volume;
- somatosensory stimulation;
- 11.7 Tesla MRI
A multislice spin echo EPI sequence was used to obtain functional MR images of the entire rat brain with blood oxygenation level dependent (BOLD) and cerebral blood volume (CBV) contrast at 11.7 T. Maps of activation incidence were created by warping each image to the Paxinos rat brain atlas and marking the extent of the activated area. Incidence maps for BOLD and CBV were similar, but activation in draining veins was more prominent in the BOLD images than in the CBV images. Cerebellar activation was observed along the surface in BOLD images, but in deeper regions in the CBV images. Both effects may be explained by increased signal dropout and distortion in the EPI images after administration of the ferumoxtran-10 contrast agent for CBV fMRI. CBV-weighted incidence maps were also created for 10, 20, and 30 mg Fe/kg doses of ferumoxtran-10. The magnitude of the average percentage change during stimulation increased from 4.9% with the 10 mg Fe/kg dose to 8.7% with the 30-mg Fe/kg dose. Incidence of activation followed a similar trend. Magn Reson Med, 2006. Published 2005 Wiley-Liss, Inc.