Full Paper

BOLD and CBV-weighted functional magnetic resonance imaging of the rat somatosensory system†

  1. Shella D. Keilholz1,
  2. Afonso C. Silva2,
  3. Mira Raman3,
  4. Hellmut Merkle2,
  5. Alan P. Koretsky2,*

Article first published online: 21 DEC 2005

DOI: 10.1002/mrm.20744

Issue

Magnetic Resonance in Medicine

Magnetic Resonance in Medicine

Volume 55, Issue 2, pages 316–324, February 2006

Additional Information

How to Cite

Keilholz, S. D., Silva, A. C., Raman, M., Merkle, H. and Koretsky, A. P. (2006), BOLD and CBV-weighted functional magnetic resonance imaging of the rat somatosensory system. Magn Reson Med, 55: 316–324. doi: 10.1002/mrm.20744

Author Information

  1. 1

    Emory University, Atlanta, Georgia, USA

  2. 2

    National Institutes of Health, Bethesda, Maryland, USA

  3. 3

    Stanford University, Palo Alto, California, USA

*Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, 10/B1D728, MSC 1065, Bethesda, MD 20892, USA

  1. †

    This article is a US Government work and, as such, is in the public domain in the United States of America.

Publication History

  1. Issue published online: 26 JAN 2006
  2. Article first published online: 21 DEC 2005
  3. Manuscript Accepted: 31 AUG 2005
  4. Manuscript Revised: 24 AUG 2005
  5. Manuscript Received: 8 MAR 2005

Funded by

  • NIH, NINDS intramural research program

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Keywords:

  • fMRI;
  • BOLD;
  • cerebral blood volume;
  • somatosensory stimulation;
  • 11.7 Tesla MRI

Abstract

A multislice spin echo EPI sequence was used to obtain functional MR images of the entire rat brain with blood oxygenation level dependent (BOLD) and cerebral blood volume (CBV) contrast at 11.7 T. Maps of activation incidence were created by warping each image to the Paxinos rat brain atlas and marking the extent of the activated area. Incidence maps for BOLD and CBV were similar, but activation in draining veins was more prominent in the BOLD images than in the CBV images. Cerebellar activation was observed along the surface in BOLD images, but in deeper regions in the CBV images. Both effects may be explained by increased signal dropout and distortion in the EPI images after administration of the ferumoxtran-10 contrast agent for CBV fMRI. CBV-weighted incidence maps were also created for 10, 20, and 30 mg Fe/kg doses of ferumoxtran-10. The magnitude of the average percentage change during stimulation increased from 4.9% with the 10 mg Fe/kg dose to 8.7% with the 30-mg Fe/kg dose. Incidence of activation followed a similar trend. Magn Reson Med, 2006. Published 2005 Wiley-Liss, Inc.

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