Full Paper

Obtaining blood oxygenation levels from MR signal behavior in the presence of single venous vessels

  1. Jan Sedlacik1,
  2. Alexander Rauscher1,2,
  3. Jürgen R. Reichenbach1,*

Article first published online: 29 OCT 2007

DOI: 10.1002/mrm.21283

Issue

Magnetic Resonance in Medicine

Magnetic Resonance in Medicine

Volume 58, Issue 5, pages 1035–1044, November 2007

Additional Information

How to Cite

Sedlacik, J., Rauscher, A. and Reichenbach, J. R. (2007), Obtaining blood oxygenation levels from MR signal behavior in the presence of single venous vessels. Magn Reson Med, 58: 1035–1044. doi: 10.1002/mrm.21283

Author Information

  1. 1

    Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University, Jena, Germany

  2. 2

    Core Unit MR Methods, Friedrich Schiller University, Jena, Germany

*Medical Physics Group, Institute of Diagnostic and Interventional Radiology, University Clinics, Friedrich Schiller University, Jena, Philosophenweg 3, Jena 07743, Germany

Publication History

  1. Issue published online: 29 OCT 2007
  2. Article first published online: 29 OCT 2007
  3. Manuscript Accepted: 3 APR 2007
  4. Manuscript Revised: 15 FEB 2007
  5. Manuscript Received: 4 MAY 2006

Funded by

  • Deutsche Forschungsgemeinschaft (DFG). Grant Number: RE 1123/7-1 and 7-2
  • Cost B21 (STSM grant). Grant Number: COST-STSM-B21-00305
  • Core Unit MR Methods. Grant Number: BMBF 01ZZ0405

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Keywords:

  • SWI;
  • BOLD;
  • fMRI;
  • Tmath image;
  • blood oxygenation;
  • carbogen;
  • single vessel;
  • cylinder model;
  • phantom;
  • multiecho

Abstract

The MR signal decay in gradient echo sequences includes signal loss due to spin dephasing caused by static magnetic field inhomogeneities. This decay can be calculated for different geometries of the susceptibility distribution, such as spheres, cylinders, or cylinder networks. In particular, the model of an infinitely long cylinder is a good approximation for single straight blood vessels. Blood oxygenation and blood volume fraction are important parameters, which influence the signal in a characteristic way. In this work the signal decays for a single cylindrical vessel were investigated and evaluated in simulations, phantom measurements as well as in vivo measurements of small single veins in the human brain by using a 3D multiecho gradient echo sequence. Good agreement between simulations and phantom experiments was obtained for different experimental settings. Based on the simulations, physiologically consistent values of venous blood oxygenation level, Y, were extracted from the in vivo measurements of different veins and volunteers (Y = 0.55 ± 0.02). The methods ability to measure changes in venous blood oxygenation induced by carbogen breathing was demonstrated in one volunteer, where an increase from Y ≈ 0.5 to Y ≈ 0.7 was observed. Magn Reson Med 58:1035–1044, 2007. © 2007 Wiley-Liss, Inc.

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