Spatial effects in the detection of γ-aminobutyric acid: Improved sensitivity at high fields using inner volume saturation
Article first published online: 29 OCT 2007
Copyright © 2007 Wiley-Liss, Inc.
Magnetic Resonance in Medicine
Volume 58, Issue 6, pages 1276–1282, December 2007
How to Cite
Edden, R. A.E. and Barker, P. B. (2007), Spatial effects in the detection of γ-aminobutyric acid: Improved sensitivity at high fields using inner volume saturation. Magn Reson Med, 58: 1276–1282. doi: 10.1002/mrm.21383
- Issue published online: 27 NOV 2007
- Article first published online: 29 OCT 2007
- Manuscript Accepted: 15 JUL 2007
- Manuscript Revised: 17 MAY 2007
- Manuscript Received: 28 DEC 2006
- National Institutes of Health (NIH). Grant Number: P41 RR15241
- magnetic resonance spectroscopy;
- 3 Tesla;
The MEGA-PRESS-IVS method has been developed, which combines MEGA (a frequency-selective editing technique) editing with the point-resolved spectroscopy sequence (PRESS) and inner volume saturation (IVS) localization, reducing the deleterious effects of spatial variation in coupling evolution. The IVS method has been previously described for improved efficiency of lactate detection. The current study demonstrates that the combination of MEGA-PRESS with IVS results in increased sensitivity for edited single-voxel measurements of glutamate and γ-aminobutyric acid (GABA). A four-compartment model of coupling evolution is investigated through simple product operators and full spin-system simulations and the predicted pattern of signal evolution is demonstrated through MEGA-PRESS-MRSI. MEGA-PRESS-IVS is then compared to MEGA-PRESS in a phantom and an average signal increase of 24% is demonstrated in five healthy volunteers. Magn Reson Med, 2007. © 2007 Wiley-Liss, Inc.