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Susceptibility weighted imaging at ultra high magnetic field strengths: Theoretical considerations and experimental results

  1. Andreas Deistung1,*,
  2. Alexander Rauscher2,
  3. Jan Sedlacik3,
  4. Jörg Stadler4,
  5. Stephan Witoszynskyj5,
  6. Jürgen R. Reichenbach1

Article first published online: 27 OCT 2008

DOI: 10.1002/mrm.21754

Issue

Magnetic Resonance in Medicine

Magnetic Resonance in Medicine

Volume 60, Issue 5, pages 1155–1168, November 2008

Additional Information

How to Cite

Deistung, A., Rauscher, A., Sedlacik, J., Stadler, J., Witoszynskyj, S. and Reichenbach, J. R. (2008), Susceptibility weighted imaging at ultra high magnetic field strengths: Theoretical considerations and experimental results. Magn Reson Med, 60: 1155–1168. doi: 10.1002/mrm.21754

Author Information

  1. 1

    Medical Physics Group, Institute for Diagnostic and Interventional Radiology, University Clinics, Friedrich Schiller-University, Jena, Germany

  2. 2

    UBC MRI Research Centre, Vancouver, British Columbia, Canada

  3. 3

    Department of Radiological Sciences, Division of Translational Imaging Research, St. Jude Children's Research Hospital, Memphis, Tennessee

  4. 4

    Leibniz Institute for Neurobiology, Magdeburg, Germany

  5. 5

    Department of Diagnostic Radiology, Medical University of Vienna, Austria

*Medical Physics Group, Institute for Diagnostic and Interventional Radiology, University Clinics, Friedrich Schiller University of Jena, Philosophenweg 3, Jena 07743, Germany

Publication History

  1. Issue published online: 27 OCT 2008
  2. Article first published online: 27 OCT 2008
  3. Manuscript Accepted: 13 JUN 2008
  4. Manuscript Revised: 6 JUN 2008
  5. Manuscript Received: 19 DEC 2007

Funded by

  • Deutsche Forschungsgemeinschaft (DFG). Grant Number: RE 1123/9-1
  • Bundesministerium für Bildung und Forschung. Grant Numbers: 01ZZ0405, 01GQ0703, 01GO0504
  • COST B21 (Short Term Scientific Missions). Grant Numbers: COST-STSM-B21-01283, COST-STSM-B21-00305
  • Startup Grant S10 of the IZKF Jena
  • Michael Smith Foundation for Health Research

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Keywords:

  • MRI;
  • SWI;
  • magnetic susceptibility;
  • phase;
  • 7T

Abstract

We present numerical simulations and experimental results for susceptibility weighted imaging (SWI) at 7 T. Magnitude, phase, and SWI contrast were simulated for different voxel geometries and imaging parameters, resulting in an echo time of 14 msec for optimum contrast between veins and surrounding tissue. Slice thickness of twice the in-plane voxel size or more resulted in optimum vessel visibility. Phantom and in vivo data are in very good agreement with the simulations and the delineation of vessels at 7 T was superior compared to lower field strengths. The phase of the complex data reveals anatomical details that are complementary to the corresponding magnitude images. Susceptibility weighted imaging at very high field strengths is a promising technique because of its high sensitivity to tissue susceptibility, its low specific absorption rate, and the phase's negligible sensitivity to B1 inhomogeneities. Magn Reson Med 60:1155–1168, 2008. © Wiley-Liss, Inc.

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