Full Paper

Comparison of normal tissue R1 and Rmath image modulation by oxygen and carbogen

  1. James P.B. O'Connor1,2,*,
  2. Josephine H. Naish1,
  3. Alan Jackson1,
  4. John C. Waterton1,3,
  5. Yvonne Watson1,
  6. Sue Cheung1,
  7. David L. Buckley1,
  8. Deirdre M. McGrath1,
  9. Giovanni A. Buonaccorsi1,
  10. Samantha J. Mills1,
  11. Caleb Roberts1,
  12. Gordon C. Jayson2,
  13. Geoff J.M. Parker1

Article first published online: 18 DEC 2008

DOI: 10.1002/mrm.21815

Issue

Magnetic Resonance in Medicine

Magnetic Resonance in Medicine

Volume 61, Issue 1, pages 75–83, January 2009

Additional Information

How to Cite

O'Connor, J. P., Naish, J. H., Jackson, A., Waterton, J. C., Watson, Y., Cheung, S., Buckley, D. L., McGrath, D. M., Buonaccorsi, G. A., Mills, S. J., Roberts, C., Jayson, G. C. and Parker, G. J. (2009), Comparison of normal tissue R1 and Rmath image modulation by oxygen and carbogen. Magnetic Resonance in Medicine, 61: 75–83. doi: 10.1002/mrm.21815

Author Information

  1. 1

    Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK

  2. 2

    Cancer Research UK Department of Medical Oncology, Christie Hospital, Manchester, UK

  3. 3

    Translational Sciences, AstraZeneca, Alderley Park, Macclesfield, Cheshire, UK

*Cancer Research UK/Royal College of Radiologists Clinical Research Training Fellow, Imaging Science and Biomedical Engineering, Stopford Building, University of Manchester, Oxford Road, Manchester, M13 9PT, UK

Publication History

  1. Issue published online: 18 DEC 2008
  2. Article first published online: 18 DEC 2008
  3. Manuscript Accepted: 13 AUG 2008
  4. Manuscript Revised: 12 JUL 2008
  5. Manuscript Received: 21 DEC 2007

Funded by

  • Cancer Research UK Clinical Research Training Fellowship Grants. Grant Numbers: C19221/A6086, C21247/A7473
  • Cancer Research UK Programme Grant. Grant Number: C237/A6295
  • Cancer Research UK is a charity registered in the United Kingdom, No. 1089464
  • AstraZeneca

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Keywords:

  • biomarker;
  • carbogen;
  • effective transverse relaxation rate;
  • longitudinal relaxation rate;
  • oxygen;
  • physiology

Abstract

Magnetic resonance imaging has shown promise for evaluating tissue oxygenation. In this study differences in the tissue longitudinal relaxation rate (R1) and effective transverse relaxation rate (Rmath image), induced by inhalation of pure oxygen and carbogen, were evaluated in 10 healthy subjects. Significant reductions in R1 were demonstrated following both oxygen and carbogen inhalation in the spleen (both P < 0.001), liver (P = 0.002 air vs. oxygen; P = 0.001 air vs. carbogen), skeletal muscle (both P < 0.001), and renal cortex (P = 0.005 air vs. oxygen; P = 0.008 air vs. carbogen). No significant change in Rmath image occurred following pure oxygen in any organ. However, a significant increase in Rmath image was observed in the spleen (P < 0.001), liver (P = 0.001), skeletal muscle (P = 0.026), and renal cortex (P = 0.001) following carbogen inhalation, an opposite effect to that observed in many studies of tumor pathophysiology. Changes in R1 and Rmath image were independent of the gas administration order in the spleen and skeletal muscle. These findings suggest that the R1 and Rmath image responses to hyperoxic gases are independent biomarkers of oxygen physiology. Magn Reson Med 61:75–83, 2009. © 2008 Wiley-Liss, Inc.

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