Note

In vivo detection of serine in the human brain by proton magnetic resonance spectroscopy (1H-MRS) at 7 Tesla

  1. Changho Choi1,*,
  2. Ivan Dimitrov1,2,
  3. Deborah Douglas1,
  4. Chenguang Zhao1,
  5. Halima Hawesa1,
  6. Subroto Ghose3,
  7. Carol A. Tamminga3

Article first published online: 12 JUN 2009

DOI: 10.1002/mrm.22079

Issue

Magnetic Resonance in Medicine

Magnetic Resonance in Medicine

Volume 62, Issue 4, pages 1042–1046, October 2009

Additional Information

How to Cite

Choi, C., Dimitrov, I., Douglas, D., Zhao, C., Hawesa, H., Ghose, S. and Tamminga, C. A. (2009), In vivo detection of serine in the human brain by proton magnetic resonance spectroscopy (1H-MRS) at 7 Tesla. Magnetic Resonance in Medicine, 62: 1042–1046. doi: 10.1002/mrm.22079

Author Information

  1. 1

    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA

  2. 2

    Philips Medical Systems, Cleveland, Ohio, USA

  3. 3

    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA

*Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390

Publication History

  1. Issue published online: 28 SEP 2009
  2. Article first published online: 12 JUN 2009
  3. Manuscript Accepted: 15 APR 2009
  4. Manuscript Revised: 26 MAR 2009
  5. Manuscript Received: 23 JAN 2009

Funded by

  • State of Texas
  • Metroplex Comprehensive Medical Imaging Center

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Keywords:

  • serine;
  • human brain;
  • 1H-MRS;
  • triple refocusing;
  • difference editing

Abstract

A single-voxel proton magnetic resonance spectroscopy (1H-MRS) filtering strategy for in vivo detection of serine (Ser) in human brain at 7T is proposed. Spectral difference of coupled resonances arising from different subecho times of triple refocusing at a constant total echo time (TE) was utilized to detect the Ser multiplet and cancel the overlapping creatine (Cr) 3.92-ppm singlet via difference editing. Dependence of the Ser signal on subecho times was investigated using density-matrix simulation incorporating the slice-selective radio frequency (RF) pulses. The simulation indicated that the difference-edited Ser CH2 multiplet at ∼3.96 ppm is maximized with (TE1, TE2, TE3) = (54, 78, 78) and (36, 152, 22) ms. The edited Ser peak amplitude was estimated, with both numerical and phantom analyses of the performance, as 83% with respect to 90° acquisition for a localized volume, ignoring relaxation effects. From the area ratio of the edited Ser and unedited Cr 3.03-ppm peaks, assuming identical T1 and T2 between Ser and Cr, the Ser-to-Cr concentration ratio for the frontal cortex of healthy adults was estimated to be 0.8 ± 0.2 (mean ± SD; N = 6). Magn Reson Med, 2009. © 2009 Wiley-Liss, Inc.

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