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Measurement of brain perfusion, blood volume, and blood-brain barrier permeability, using dynamic contrast-enhanced T1-weighted MRI at 3 tesla

  1. Henrik B. W. Larsson1,2,3,4,*,
  2. Frédéric Courivaud5,
  3. Egill Rostrup1,3,4,
  4. Adam E. Hansen1,6

Article first published online: 24 SEP 2009

DOI: 10.1002/mrm.22136

Issue

Magnetic Resonance in Medicine

Magnetic Resonance in Medicine

Volume 62, Issue 5, pages 1270–1281, November 2009

Additional Information

How to Cite

Larsson, H. B. W., Courivaud, F., Rostrup, E. and Hansen, A. E. (2009), Measurement of brain perfusion, blood volume, and blood-brain barrier permeability, using dynamic contrast-enhanced T1-weighted MRI at 3 tesla. Magn. Reson. Med., 62: 1270–1281. doi: 10.1002/mrm.22136

Author Information

  1. 1

    Functional Imaging Unit, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark

  2. 2

    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

  3. 3

    Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark

  4. 4

    The Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

  5. 5

    The Interventional Centre, Rikshospitalet, Oslo, Norway

  6. 6

    Department of Radiology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark

*Functional Imaging Unit, Glostrup Hospital, University of Copenhagen, Ndr. Ringvej 57, DK-2600 Glostrup, Copenhagen, Denmark

Publication History

  1. Issue published online: 28 OCT 2009
  2. Article first published online: 24 SEP 2009
  3. Manuscript Accepted: 16 JUN 2009
  4. Manuscript Revised: 4 JUN 2009
  5. Manuscript Received: 17 OCT 2008

Funded by

  • Memorial Grant of Merchant Sigurd Abrahamson
  • Wife Addie Abrahamson and the Lundbeck Foundation (through the Center for Neurovascular Signaling (Lucens))

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Keywords:

  • dynamic contrast-enhanced MRI;
  • T1-weighted MRI;
  • brain perfusion;
  • blood brain barrier;
  • brain blood volume;
  • brain tumor

Abstract

Assessment of vascular properties is essential to diagnosis and follow-up and basic understanding of pathogenesis in brain tumors. In this study, a procedure is presented that allows concurrent estimation of cerebral perfusion, blood volume, and blood-brain permeability from dynamic T1-weighted imaging of a bolus of a paramagnetic contrast agent passing through the brain. The methods are applied in patients with brain tumors and in healthy subjects. Perfusion was estimated by model-free deconvolution using Tikhonov's method (gray matter/white matter/tumor: 72 ± 16/30 ± 8/56 ± 45 mL/100 g/min); blood volume (6 ± 2/4 ± 1/7 ± 6 mL/100 g) and permeability (0.9 ± 0.4/0.8 ± 0.3/3 ± 5 mL/100 g/min) were estimated by using Patlak's method and a two-compartment model. A corroboration of these results was achieved by using model simulation. In addition, it was possible to generate maps on a pixel-by-pixel basis of cerebral perfusion, cerebral blood volume, and blood-brain barrier permeability. Magn Reson Med, 2009. © 2009 Wiley-Liss, Inc.

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