Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate
Article first published online: 23 APR 2010
Copyright © 2010 Wiley-Liss, Inc.
Magnetic Resonance in Medicine
Volume 63, Issue 5, pages 1137–1143, May 2010
How to Cite
Hurd, R. E., Yen, Y.-F., Mayer, D., Chen, A., Wilson, D., Kohler, S., Bok, R., Vigneron, D., Kurhanewicz, J., Tropp, J., Spielman, D. and Pfefferbaum, A. (2010), Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate. Magn Reson Med, 63: 1137–1143. doi: 10.1002/mrm.22364
- Issue published online: 23 APR 2010
- Article first published online: 23 APR 2010
- Manuscript Accepted: 21 DEC 2009
- Manuscript Revised: 30 NOV 2009
- Manuscript Received: 6 JUL 2009
- NIH. Grant Numbers: EB009070, P41RR09784, AA005965, AA013521-INIA
Formulation, polarization, and dissolution conditions were developed to obtain a stable hyperpolarized solution of [1-13C]-ethyl pyruvate. A maximum tolerated concentration and injection rate were determined, and 13C spectroscopic imaging was used to compare the uptake of hyperpolarized [1-13C]-ethyl pyruvate relative to hyperpolarized [1-13C]-pyruvate into anesthetized rat brain. Hyperpolarized [1-13C]-ethyl pyruvate and [1-13C]-pyruvate metabolic imaging in normal brain is demonstrated and quantified in this feasibility and range-finding study. Magn Reson Med 63:1137–1143, 2010. © 2010 Wiley-Liss, Inc.