• 1
    Golman K, in't Zandt R, Lerche M, Pehrson R, Ardenkjaer-Larsen JH. Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis. Cancer Res 2006; 66: 1085510860.
  • 2
    Golman K, Petersson JS, Magnusson P, Johansson E, Akeson P, Chai CM, Hansson G, Månsson S. Cardiac metabolism measured noninvasively by hyperpolarized 13C MRI. Magn Reson Med 2008; 59: 10051013.
  • 3
    Albers MJ, Bok R, Chen AP, Cunningham CH, Zierhut ML, Zhang VY, Kohler SJ, Tropp J, Hurd RE, Yen YF, Nelson SJ, Vigneron DB, Kurhanewicz J. Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. Cancer Res 2008; 68: 86078615.
  • 4
    Chen AP, Albers MJ, Cunningham CH, Kohler SJ, Yen YF, Hurd RE, Tropp J, Bok R, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T: initial experience. Magn Reson Med 2007; 58: 10991106.
  • 5
    Day SE, Kettunen MI, Gallagher FA, Hu D-E, Lerche M, Wolber J, Golman K, Ardenkjaer-Larsen JH, Brindle KM. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy. Nat Med 2007; 13: 13821387.
  • 6
    Chen AP, Bok R, Zhang V, Xu D, Veeraraghavan S, Hurd RE, Nelson SJ, Kurhanewicz J, Vigneron DB. Serial hyperpolarized 13C 3D-MRSI following therapy in a mouse model of prostate cancer. In: Proceedings of the 16th Annual Meeting of ISMRM, Toronto, Canada, 2008. p 888.
  • 7
    Cremer JE, Cunningham VJ, Pardridge WM, Braun LD, Oldendorf WH. Kinetics of blood-brain barrier transport of pyruvate, lactate and glucose in sucking, weanling and adult rats. J Neurochem 1979; 33: 439445.
  • 8
    Miller LP, Oldendorf WH. Regional kinetic constants for blood-brain barrier pyruvic acid transport in conscious rats by the monocarboxylic acid carrier. J Neurochem 1986; 46: 14121416.
  • 9
    Pardridge WM. Brain metabolism: a perspective from the blood-brain barrier. Am Physiol Soc 1983; 63: 14811527.
  • 10
    Fink MP. Ethyl pyruvate: a novel anti-inflammatory agent. J Intern Med 2007; 261: 349362.
  • 11
    Cho IH, Kim SW, Kim JB, Kim TK, Lee KW, Han PL, Lee JK. Ethyl pyruvate attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. J Neurosci Res 2006; 15: 15051511.
  • 12
    Yu YM, Kim JB, Lee KW, Kim SY, Han PL, Lee JK. Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window. Stroke 2005; 36: 22382243.
  • 13
    Bennett-Guerrero E, Swaminathan M, Grigore AM, Roach GW, Aberle LG, Johnston JM, Fink MP. A phase II multicenter double-blind placebo-controlled study of ethyl pyruvate in high-risk patients undergoing cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth 2009; 23: 324329.
  • 14
    Kohler SJ, Yen Y-F, Wolber J, Chen AP, Albers MJ, Bok R, Zhang V, Tropp J, Nelson SJ, Vigneron DB, Kurhanewicz J, Hurd RE. In vivo 13carbon metabolic imaging at 3T with hyperpolarized 13C-1-pyruvate. Magn Reson Med 2007; 58: 6569.
  • 15
    Leung KK-C, Lam WW, Chen AP, Cunningham CH. Kinetic modeling of hyperpolarized [1-13C] pyruvate metabolism in blood. In: Proceedings of the 17th Annual Meeting of ISMRM, Honolulu, Hawaii, 2009. p 2432.
  • 16
    Julien-Dolbec C, Tropres I, Montigon O, Reutenauer H, Ziegler A, Decorps M, Payen JF. Regional response of cerebral blood volume to graded hypoxic hypoxia in rat brain. Br J Anaesth 2002; 89: 287293.
  • 17
    Leegsma-Vogt G, van der Werf S, Venema K, Korf J. Modeling cerebral arteriovenous lactate kinetics after intravenous lactate infusion in the rat. J Cereb Blood Flow Metab 2004; 24: 10711080.
  • 18
    Lear JL, Kasliwal RK. Autoradiographic measurement of cerebral lactate transport rate constants in normal and activated conditions. J Cereb Blood Flow Metab 1991; 11: 576580.