Imaging Methodology - Full Paper

Rapid multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart

  1. Angus Z. Lau1,2,*,
  2. Albert P. Chen3,
  3. Nilesh R. Ghugre2,
  4. Venkat Ramanan2,
  5. Wilfred W. Lam2,
  6. Kim A. Connelly4,
  7. Graham A. Wright1,2,
  8. Charles H. Cunningham1,2

Article first published online: 26 OCT 2010

DOI: 10.1002/mrm.22525

Issue

Magnetic Resonance in Medicine

Magnetic Resonance in Medicine

Volume 64, Issue 5, pages 1323–1331, November 2010

Additional Information

How to Cite

Lau, A. Z., Chen, A. P., Ghugre, N. R., Ramanan, V., Lam, W. W., Connelly, K. A., Wright, G. A. and Cunningham, C. H. (2010), Rapid multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart. Magn. Reson. Med., 64: 1323–1331. doi: 10.1002/mrm.22525

Author Information

  1. 1

    Department of Medical Biophysics, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada

  2. 2

    Imaging Research, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

  3. 3

    GE Healthcare, Toronto, Ontario, Canada

  4. 4

    Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada

*Candidate, Imaging Research (S119), Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Toronto, Ontario, Canada, M4N 3M5

Publication History

  1. Issue published online: 26 OCT 2010
  2. Article first published online: 26 OCT 2010
  3. Manuscript Accepted: 14 MAY 2010
  4. Manuscript Revised: 19 APR 2010
  5. Manuscript Received: 7 OCT 2009

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Keywords:

  • cardiac metabolism;
  • hyperpolarized 13C;
  • metabolic imaging;
  • pyruvate;
  • bicarbonate;
  • pulse sequences;
  • RF pulses

Abstract

Hyperpolarization of spins via dynamic nuclear polarization (DNP) has been explored as a method to non-invasively study real-time metabolic rocesses occurring in vivo using 13C-labeled substrates. Recently, hyperpolarized 13C pyruvate has been used to characterize in vivo cardiac metabolism in the rat and pig. Conventional 3D spectroscopic imaging methods require in excess of 100 excitations, making it challenging to acquire a full cardiac-gated, breath-held, whole-heart volume. In this article, the development of a rapid multislice cardiac-gated spiral 13C imaging pulse sequence consisting of a large flip-angle spectral-spatial excitation RF pulse combined with a single-shot spiral k-space trajectory for rapid imaging of cardiac metabolism is described. This sequence permits whole-heart coverage (6 slices, 8.8-mm in-plane resolution) in any plane, allowing imaging of the metabolites of interest, [1- 13C] pyruvate, [1- 13C] lactate, and 13C bicarbonate, within a single breathhold. Pyruvate and bicarbonate cardiac volumes were acquired, while lactate images were not acquired due to low lactate levels in the animal model studied. The sequence was demonstrated with phantom experiments and in vivo testing in a pig model. Magn Reson Med, 2010. © 2010 Wiley-Liss, Inc.

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