Biophysics & Basic Biomedical Research-Full Papers
An in vivo verification of the intravoxel incoherent motion effect in diffusion-weighted imaging of the abdomen
Article first published online: 27 JUL 2010
Copyright © 2010 Wiley-Liss, Inc.
Magnetic Resonance in Medicine
Volume 64, Issue 6, pages 1580–1585, December 2010
How to Cite
Lemke, A., Laun, F. B., Simon, D., Stieltjes, B. and Schad, L. R. (2010), An in vivo verification of the intravoxel incoherent motion effect in diffusion-weighted imaging of the abdomen. Magn Reson Med, 64: 1580–1585. doi: 10.1002/mrm.22565
- Issue published online: 23 NOV 2010
- Article first published online: 27 JUL 2010
- Manuscript Accepted: 16 JUN 2010
- Manuscript Revised: 10 JUN 2010
- Manuscript Received: 3 DEC 2009
- relaxation effects
To investigate the vascular contribution to the measured apparent diffusion coefficient and to validate the Intra Voxel Incoherent Motion theory, the signal as a function of the b-value was measured in the healthy pancreas with and without suppression of the vascular component and under varying echo times (TE = 50, 70, and 100 msec). The perfusion fraction f and the diffusion coefficient D were extracted from the measured DW-data using the original Intra Voxel Incoherent Motion-equation and a modified version of this equation incorporating relaxation effects. First, the perfusion fraction f in the blood suppressed pancreatic tissue decreased significantly (P = 0.03), whereas the diffusion coefficient D did not change with suppression (P = 0.43). Second, the perfusion fraction f increased significantly with increasing echo time (P = 0.0025), whereas the relaxation time compensated perfusion fraction f′ showed no significant dependence on TE (P = 0.31). These results verify a vascular contribution to the diffusion weighted imaging measurement at low b values and support the Intra Voxel Incoherent Motion-theory. Magn Reson Med, 2010. © 2010 Wiley-Liss, Inc.