The effect of reducing repetition time TR on the measurement of liver R2 for the purpose of measuring liver iron concentration
Version of Record online: 30 NOV 2010
Copyright © 2010 Wiley-Liss, Inc.
Magnetic Resonance in Medicine
Volume 65, Issue 5, pages 1346–1351, May 2011
How to Cite
Pavitt, H. L., Aydinok, Y., El-Beshlawy, A., Bayraktaroglu, S., Ibrahim, A. S., Hamdy, M. M., Pang, W., Sharples, C. and St Pierre, T. G. (2011), The effect of reducing repetition time TR on the measurement of liver R2 for the purpose of measuring liver iron concentration. Magn Reson Med, 65: 1346–1351. doi: 10.1002/mrm.22712
- Issue online: 15 APR 2011
- Version of Record online: 30 NOV 2010
- Manuscript Accepted: 8 OCT 2010
- Manuscript Revised: 4 OCT 2010
- Manuscript Received: 18 NOV 2009
- magnetic resonance imaging;
- iron overload;
- liver iron concentration
The effects of reducing the pulse repetition time from 2500 ms to 1000 ms when using spin-density-projection-assisted R2-magnetic resonance imaging for the purpose of measuring liver iron concentration were evaluated. Repeated liver R2 measurements were made using both protocols on 60 subjects with liver iron concentrations ranging from 0.5 to 48.6 mg Fe (g dry tissue)−1. The mean total scan time at repetition time 1000 ms was 42% of that at repetition time 2500 ms. The repeatability coefficients for the two protocols were not significantly different from each other. A systematic difference in the measured R2 using each protocol was found indicating that an adjustment factor is required when one protocol is used to replace the other. The 95% limits of agreement between the two protocols were not significantly different from their repeatability coefficients indicating that the protocols can be interchanged without any significant change in accuracy or precision of liver iron concentration measurement. Magn Reson Med, 2011. © 2010 Wiley-Liss, Inc.